Document Detail

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.
MedLine Citation:
PMID:  25071163     Owner:  NLM     Status:  MEDLINE    
Eosinophils natively inhabit the small intestine, but a functional role for them there has remained elusive. Here, we show that eosinophil-deficient mice were protected from induction of Th2-mediated peanut food allergy and anaphylaxis, and Th2 priming was restored by reconstitution with il4(+/+) or il4(-/-) eosinophils. Eosinophils controlled CD103(+) dendritic cell (DC) activation and migration from the intestine to draining lymph nodes, events necessary for Th2 priming. Eosinophil activation in vitro and in vivo led to degranulation of eosinophil peroxidase, a granule protein whose enzymatic activity promoted DC activation in mice and humans in vitro, and intestinal and extraintestinal mouse DC activation and mobilization to lymph nodes in vivo. Further, eosinophil peroxidase enhanced responses to ovalbumin seen after immunization. Thus, eosinophils can be critical contributors to the intestinal immune system, and granule-mediated shaping of DC responses can promote both intestinal and extraintestinal adaptive immunity.
Derek K Chu; Rodrigo Jimenez-Saiz; Christopher P Verschoor; Tina D Walker; Susanna Goncharova; Alba Llop-Guevara; Pamela Shen; Melissa E Gordon; Nicole G Barra; Jennifer D Bassett; Joshua Kong; Ramzi Fattouh; Kathy D McCoy; Dawn M Bowdish; Jonas S Erjefält; Oliver Pabst; Alison A Humbles; Roland Kolbeck; Susan Waserman; Manel Jordana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  211     ISSN:  1540-9538     ISO Abbreviation:  J. Exp. Med.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-29     Completed Date:  2014-09-22     Revised Date:  2014-10-06    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1657-72     Citation Subset:  IM    
Copyright Information:
© 2014 Chu et al.
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MeSH Terms
Adaptive Immunity / drug effects,  immunology*
Antigen-Presenting Cells / drug effects,  immunology
Antigens, CD / metabolism
Antigens, CD11c / metabolism
Cell Degranulation / drug effects
Cell Movement / drug effects
Cross-Priming / drug effects,  immunology
Dendritic Cells / drug effects,  immunology*
Eosinophils / immunology*,  ultrastructure
Erythropoietin / pharmacology
Gastrointestinal Tract / cytology*
Integrin alpha Chains / metabolism
Interleukin-4 / biosynthesis
Th2 Cells / drug effects,  immunology*
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD11c; 0/Integrin alpha Chains; 0/alpha E integrins; 11096-26-7/Erythropoietin; 207137-56-2/Interleukin-4
Comment In:
Nat Rev Immunol. 2014 Sep;14(9):580-1   [PMID:  25103355 ]

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