Document Detail

Indices of vascular stiffness and wave reflection in relation to body mass index or body fat in healthy subjects.
MedLine Citation:
PMID:  17714086     Owner:  NLM     Status:  MEDLINE    
1. Obesity appears to influence vascular stiffness, an important cardiovascular risk factor. An accurate picture of arterial stiffness may be obtained when a combination of various techniques is used. 2. The purpose of the present study was to assess whether the body mass index (BMI) and body fat content obtained by bioimpedance were of equal value in estimating the influence of body fatness on various indices of vascular stiffness and wave reflection. 3. A total of 175 healthy subjects was studied. Anthropometric measurements and total body bio-impedance analysis were performed to assess fat mass as a proportion of total body composition. Arterial stiffness and wave reflection were assessed using digital volume pulse analysis and tonometric measurement of the wave reflection indices and central haemodynamics. 4. Significant differences in the stiffness index (SI(DVP); P < 0.0001), peripheral augmentation index (pAI(x); P < 0.0001), central augmentation index (cAI(x); P < 0.0001), peripheral pulse pressure (pPP; P = 0.026) and central pulse pressure (cPP; P < 0.0001) were found when the population examined was divided accordingly to tertile of body fat content. However, subdividing various indices of arterial stiffness according to the tertile of BMI did not reveal any significant differences between groups, except for pPP and cPP. 5. Body fat content was significantly correlated with SI(DVP), pAI(x), cAI(x), pPP and cPP. The BMI correlated weakly with SI(DVP), pPP and cPP. 6. In conclusion, the BMI is not very useful in predicting changes in arterial stiffness and wave reflection due to obesity. However, stiffness and wave reflection indices derived from digital volume pulse analysis, the characteristics of radial and aortic pressure waveforms and peripheral and aortic pulse pressure are all related to body fat content, as estimated by bioimpedance.
Andrzej Wykretowicz; Karolina Adamska; Przemyslaw Guzik; Tomasz Krauze; Henryk Wysocki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  34     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-23     Completed Date:  2007-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1005-9     Citation Subset:  IM    
Department of Internal Medicine, Division of Cardiology-Intensive Therapy, University School of Medicine, Poznan, Poland.
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MeSH Terms
Adipose Tissue / physiology*
Blood Pressure / physiology
Blood Vessels / physiology*
Body Composition / physiology
Body Mass Index*
Electric Impedance
Heart Rate / physiology
Middle Aged
Muscle Tonus / physiology
Obesity / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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