Document Detail

Indices of iron and copper status during experimentally induced, marginal zinc deficiency in humans.
MedLine Citation:
PMID:  1381939     Owner:  NLM     Status:  MEDLINE    
This study examined the effect of diet-induced, marginal zinc deficiency for 7 wks in 15 men (aged 25.3 +/- 3.3 yrs; mean +/- SD) on selected indices of iron and copper status. The regimen involved low-zinc diets based on egg albumin and soy protein with added phytate and calcium such that mean [phytate]/[Zn] and [phytate] X [Ca]/[Zn] molar ratios were 209 and 4116, respectively, for 1 wk, followed by 70 and 2000, respectively, for 6 wks. Subjects were then repleted with 30 mg Zn/d for 2 wks. Plasma copper, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activity in plasma and red blood cells (RBC), hemoglobin, hematocrit, and serum ferritin were determined weekly on fasting blood samples. Significant reductions (p less than 0.05) after 7 wks in RBC Cu,Zn-superoxide dismutase (49.5 +/- 7.2 vs 33.6 +/- 6.3 U/mg Hb) and serum ferritin (69.2 +/- 38.7 vs 53.8 +/- 33.7 micrograms/L) occurred; no comparable decline was noted for plasma Cu, hemoglobin, or hematocrit. Significant (p less than 0.05) but less consistent changes were also observed in plasma superoxide dismutase activity. None of the changes were associated with the decreases in plasma, urinary and hair zinc concentrations, and alkaline phosphatase activity in RBC membranes. Results indicate that the biochemical iron and copper status of the subjects was marginally impaired, probably from the dietary regimen that induced marginal zinc deficiency.
M Ruz; K R Cavan; W J Bettger; P W Fischer; R S Gibson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  34     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  197-212     Citation Subset:  IM    
Division of Applied Human Nutrition, University of Guelph, Ontario, Canada.
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MeSH Terms
Calcium / pharmacology
Copper / metabolism*
Erythrocytes / enzymology
Ferritins / blood
Iron / metabolism*
Phytic Acid / pharmacology
Superoxide Dismutase / blood
Zinc / deficiency*
Reg. No./Substance:
7439-89-6/Iron; 7440-50-8/Copper; 7440-66-6/Zinc; 7440-70-2/Calcium; 83-86-3/Phytic Acid; 9007-73-2/Ferritins; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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