| Indices of inflammatory cell activity and pulmonary function in different stages of sarcoidosis. | |
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MedLine Citation:
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PMID: 7051763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was carried out to compare radiological and physiological changes in sarcoidosis with biochemical markers for inflammatory cell populations. Of 53 patients with sarcoidosis, 28 had respiratory symptoms and 30 past or present bilateral hilar adenopathy without symptoms. A clinical score based on lung function tests and radiological findings correlated well with elevations of lysozyme and beta2-microglobulin in serum, indicating increased inflammatory cell activity in patients with more severe lung affection. A covariation between beta2-microglobulin and lysozyme was found, suggesting concomitant activation of macrophages and lymphocytes in sarcoidosis. Serum levels of lactoferrin were elevated in patients with a disease of short duration but did not correlate with the severity of the lung affection. The closing volume also seems to be abnormal in the early course of the disease, while elevated lysozyme and beta2-microglobulin levels rather seem to reflect the extent of the pulmonary affection. |
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Authors:
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B Schmekel; R Hällgren; G Stålenheim; P Venge |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta medica Scandinavica Volume: 211 ISSN: 0001-6101 ISO Abbreviation: Acta Med Scand Publication Date: 1982 |
Date Detail:
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Created Date: 1982-10-12 Completed Date: 1982-10-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370330 Medline TA: Acta Med Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 393-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Inflammation* Lactoferrin / blood Lung / radiography Lung Diseases / blood, pathology, physiopathology* Male Middle Aged Muramidase / blood Respiratory Function Tests Sarcoidosis / blood, pathology, physiopathology* beta 2-Microglobulin / blood |
| Chemical | |
Reg. No./Substance:
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0/Lactoferrin; 0/beta 2-Microglobulin; EC 3.2.1.17/Muramidase |
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