Document Detail

Indicator measurement in tissues: CT with iohexol versus storage-phosphor autoradiography with carbon-14-labeled inulin.
MedLine Citation:
PMID:  9809079     Owner:  NLM     Status:  MEDLINE    
RATIONALE AND OBJECTIVES: Computed tomography (CT) provides accurate measurement of blood iodine concentration in vivo, as well as in phantoms simulating tissue; however, its ability to measure radiopaque agents in biologic tissues in comparison with a standard technique does not seem to have been demonstrated. To validate the performance of CT imaging for quantification of contrast media in a variety of biologic tissues in vivo, a comparison between CT imaging with an iodinated contrast agent (iohexol) and the reference tracer quantification technique (storage-phosphor autoradiography with carbon-14-labeled inulin) was performed. MATERIALS AND METHODS: Six New Zealand White rabbits were injected intravenously with a cocktail of iohexol and C-14-labeled inulin at different dose ratios and sacrificed shortly after injection to arrest blood flow at different stages of tissue tracer distribution. One rabbit received no iohexol-inulin mixture and provided baseline data. Liver, spleen, kidneys, testis, and heart were excised and rapidly frozen. Each organ was scanned with CT (1-mm contiguous sections) to determine tissue iodine distribution. Twenty-micrometer tissue slices were made in the same planes in which the CT images had been acquired, and storage-phosphor screen autoradiography was performed to quantify C-14-labeled inulin distribution. RESULTS: Digital image analysis of CT images and autoradiograms was performed on spatially matched regions, and resultant tracer concentrations were compared. Tracer concentrations were highly correlated, with resultant R2 values exceeding 0.9 in all tissues. CONCLUSION: The highly correlated results for iodinated tracer quantification in tissues for CT versus those obtained with the reference technique validate the performance of CT as an accurate means of measuring concentration of radiopaque agent in tissue, independent of tracer dose.
K R Whiteman; G L Wolf
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Academic radiology     Volume:  5     ISSN:  1076-6332     ISO Abbreviation:  Acad Radiol     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-22     Completed Date:  1999-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  799-803     Citation Subset:  IM    
Department of Radiology, Massachusetts General Hospital, Charlestown 02129, USA.
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MeSH Terms
Carbon Radioisotopes / pharmacokinetics*
Contrast Media / pharmacokinetics*
Inulin / diagnostic use,  pharmacokinetics*
Iohexol / pharmacokinetics*
Kidney Function Tests
Sensitivity and Specificity
Tissue Distribution
Tomography, X-Ray Computed*
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Contrast Media; 66108-95-0/Iohexol; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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