| Indications of vascular endothelial cell dysfunction in systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 3500677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibrinolytic and other factors have been measured in 73 patients with systemic lupus erythematosus or related conditions to determine whether clinical thrombosis, a common feature of these disorders, is associated with defective fibrinolysis. Twenty five of 72 (35%) patients, compared with two of 22 (9%) controls, showed a low level of plasminogen activator activity in response to venous occlusion, suggesting decreased fibrinolytic potential. In addition, mean plasma levels of von Willebrand factor antigen and fibronectin were markedly raised in the patients (mean (SD) 384.5 (277)% and 727 (436) mg/l respectively) compared with healthy controls (100 (50)% and 306 (65) mg/l). These data suggest a degree of endothelial cell dysfunction. No clear correlation was found between a history of thrombosis and any plasma factor measured, except for prolongation of clotting tests suggestive of the 'lupus anticoagulant'. |
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Authors:
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M A Byron; M J Allington; H M Chapel; A G Mowat; S A Cederholm-Williams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 46 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1987-12-31 Completed Date: 1987-12-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 741-5 Citation Subset: IM |
Affiliation:
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Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens / analysis Endothelium, Vascular / metabolism Female Fibrinolysis* Fibronectins / blood Humans Lupus Erythematosus, Systemic / blood*, immunology, metabolism Male Plasminogen Activators / blood Thrombosis / blood* von Willebrand Factor / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Fibronectins; 0/von Willebrand Factor; EC 3.4.21.-/Plasminogen Activators |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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