Document Detail

Indications for stereotactically-guided vacuum-assisted breast biopsy for patients with category 3 microcalcifications.
MedLine Citation:
PMID:  17690506     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Since microcalcifications classified as category 3 on mammography include not only malignant lesions but also benign lesions, it is difficult to decide whether stereotactic vacuum-assisted breast biopsy (Mammotome(R), MMT) should be performed or the patient should merely be follows. The purpose of this study is to adequately diagnose microcalcifications classified as category 3 and to formulate a correct clinical policy. In addition, we examined the characteristics of the calcifications. METHODS: This study included 51 patients who underwent MMT from July 2003 to October 2004. All the cases were evaluated as category 3, and no abnormal findings were detected on ultrasonography. We classified the pattern of calcifications based on three aspects: 1. density and size, 2. pleomorphic appearance 3. number of calcifications per square centimeter. RESULTS: Of the 51 patients, 14 were histologically diagnosed with ductal carcinoma in situ (DCIS). Heterogeneity in the density and size were observed in 9 of 14 patients (64.3%). The calcifications had a pleomorphic appearance in 6 of 14 patients (42.9%). A large number of calcifications (20/cm(2)) were observed in 8 of 14 patients (57.1%). Better examination characteristics were obtained with heterogeneity in density and size (AUC=0.72 95%C.I: 0.56-0.89) compared with pleomorphic appearance and the number of calcifications per square centimeter. The potential for malignancy was an average of 6 times higher for calcifications with heterogeneity in density and size compared to that for calcifications which were homogeneous in these aspects. CONCLUSION: Attention should be paid to prevent unnecessary mammotome procedures. Heterogeneity in the density and size of calcifications is a reliable criterion for clinical decision-making.
Mari Kikuchi; Hiroko Tsunoda-Shimizu; Tomonorii Kawasaki; Koyu Suzuki; Seigo Nakamura; Hiroshi Yagata; Koichiro Tsugawa; Osamu Takahashi
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Breast cancer (Tokyo, Japan)     Volume:  14     ISSN:  1340-6868     ISO Abbreviation:  Breast Cancer     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888201     Medline TA:  Breast Cancer     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  285-91     Citation Subset:  IM    
Department of Radiology, St.Luke's International Hospital, Tokyo, Japan.
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MeSH Terms
Biopsy, Fine-Needle / methods*
Breast Neoplasms / diagnosis*,  pathology,  radiography,  ultrasonography
Calcinosis / diagnosis*,  pathology,  radiography,  ultrasonography
Carcinoma, Intraductal, Noninfiltrating / diagnosis*,  pathology,  radiography,  ultrasonography
Middle Aged
Predictive Value of Tests
Stereotaxic Techniques
Ultrasonography, Interventional
Ultrasonography, Mammary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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