Document Detail

Indications of 'atopic bowel' in patients with self-reported food hypersensitivity.
MedLine Citation:
PMID:  20163379     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An association between atopic disease and gastrointestinal complaints has been suggested. AIM: To explore the association between atopic disease, gastrointestinal symptoms, and possible gastrointestinal manifestations of atopic disease in patients with self-reported food hypersensitivity. METHODS: Symptoms, skin prick tests, serum markers of allergy and intestinal permeability were recorded in 71 adult patients. Eosinophils, tryptase- and IgE-positive cells were counted in duodenal biopsies. RESULTS: Sixty-six (93%) patients had irritable bowel syndrome (IBS) and 43 (61%) had atopic disease, predominantly rhinoconjunctivitis. All 43 were sensitized to inhalant allergens, 29 (41%) to food allergens, but food challenges were negative. Serum total IgE and duodenal IgE-positive cell counts were significantly correlated (P < 0.0001) and both were significantly higher in atopic than in non-atopic patients (P < 0.0001 and P = 0.003 respectively). IgE-positive cells appeared to be 'armed' mast cells. Intestinal permeability was significantly elevated in atopic compared with non-atopic patients (P = 0.02). Gastrointestinal symptoms and numbers of tryptase-positive mast cells and eosinophils did not differ between groups. CONCLUSIONS: Patients with self-reported food hypersensitivity had a high prevalence of IBS and atopic disease. Atopic patients had increased intestinal permeability and density of IgE-bearing cells compared with non-atopic patients, but gastrointestinal symptoms did not differ between groups.
K Lillestøl; L Helgeland; G Arslan Lied; E Florvaag; J Valeur; R Lind; A Berstad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-16
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  31     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1112-22     Citation Subset:  IM    
Institute of Medicine, University of Bergen, Norway. <>
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MeSH Terms
Allergens / immunology
Biological Markers / blood
Food Hypersensitivity / complications,  epidemiology,  pathology
Gastrointestinal Diseases / complications*,  epidemiology,  pathology
Immunoglobulin E / immunology*,  metabolism
Inflammatory Bowel Diseases / complications*,  epidemiology,  pathology
Middle Aged
Skin Tests / methods
Young Adult
Reg. No./Substance:
0/Allergens; 0/Biological Markers; 37341-29-0/Immunoglobulin E

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