| Indication of the radiofrequency induced lesion size by pre-ablation measurements. | |
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MedLine Citation:
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PMID: 16216752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: During radiofrequency ablation of arrhythmias tissue heating and hence lesion size depend on electrode-tissue contact and cooling of the electrode tip caused by cavitary blood flow. These factors are unique and unknown for each catheter placement in the beating heart. A tool for assessing these factors prior to ablation may indicate the lesion size which will be obtained for any given catheter position. METHODS AND RESULTS: Radiofrequency ablation was performed in vitro on strips of left ventricular porcine myocardium during two different levels of convective cooling (0 or 0.1 m/s), two different contact pressures (10 or 30 g) and parallel or perpendicular electrode-tissue orientation using 7F 4 mm tip catheters. Prior to ablation the impedance rise (DeltaIMP) caused by the obtained contact and the temperature rise with a 0.6 W 5 s test pulse (DeltaT) were measured. Subsequently, during unchanged conditions, radiofrequency ablation was performed as either temperature-controlled, power-controlled or irrigated tip ablation and lesion size was determined. DeltaIMP increased significantly (P < 0.05) by improved contact, whereas it was not affected by convective cooling. DeltaT was significantly increased by increasing contact pressure (P < 0.05) and significantly decreased by increased cooling (P < 0.001). DeltaT was not systematically affected by electrode orientation. The product of DeltaT and DeltaIMP showed a significant correlation between the obtained lesion size and power output for temperature-controlled and between lesion size and tip temperature for power-controlled ablation (P < 0.001). CONCLUSIONS: Pre-ablation measurement of DeltaIMP and DeltaT can indicate the lesion size resulting after ablation in temperature-controlled, power-controlled and irrigated ablation in vitro, since DeltaT reflects cavitary cooling and to a smaller extent electrode-tissue contact, and DeltaIMP reflects only electrode-tissue contact. |
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Authors:
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Niels Stagegaard; Helen Høgh Petersen; Xu Chen; Jesper Hastrup Svendsen |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-08 |
Journal Detail:
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Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Volume: 7 ISSN: 1099-5129 ISO Abbreviation: Europace Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-11 Completed Date: 2006-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100883649 Medline TA: Europace Country: England |
Other Details:
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Languages: eng Pagination: 525-34 Citation Subset: IM |
Affiliation:
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Medical Department B 2012, The Heart Centre, Rigshospitalet, National University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catheter Ablation* Electric Impedance Irrigation Myocardium / pathology* Swine Temperature |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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