Document Detail

Indication of liver transplantation for jaundice-free biliary atresia with portal hypertension.
MedLine Citation:
PMID:  22210415     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: At the present time, indications of liver transplantation (LT) for jaundice-free biliary atresia (BA) patients include intractable cholangitis, portal hypertension and pulmonary vascular disorders. However, the timing of LT remains unclear. In the current study, we describe the therapeutic strategies for jaundice-free BA patients.
MATERIAL/METHODS: 129 BA patients were undergone LDLT between May, 2001 and April, 2010 in the Department of Transplant Surgery, Jichi Medical University, Japan.
RESULTS: The indications of LDLT for jaundice-free BA patients was 30 patients (30/129, 23%), and included portal hypertension (16 patients, 53%). Among the 16 patients with portal hypertension, there were 7 patients (7/16, 23%) in which uncontrollable gastrointestinal bleeding was an indication of LDLT. There were 5 patients (5/7; 71%) in which bleeding sites were not identified, and 3 patients (3/7; 43%) in which supportive treatments against collateral vessels were performed as a previous treatment.
CONCLUSIONS: Even in jaundice-free BA patients, after supportive treatments for portal hypertension are performed, it is necessary to assess the esophageal and gastrointestinal varices regularly and to also prepare for LT simultaneously because there is a probability of the complication of uncontrollable gastrointestinal bleeding.
Yukihiro Sanada; Koichi Mizuta; Taizen Urahashi; Yoshiyuki Ihara; Taiichi Wakiya; Noriki Okada; Naoya Yamada; Satoshi Egami; Kentaro Ushijima; Shinya Otomo; Koichi Sakamoto; Yoshikazu Yasuda; Hideo Kawarasaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of transplantation : quarterly of the Polish Transplantation Society     Volume:  16     ISSN:  2329-0358     ISO Abbreviation:  Ann. Transplant.     Publication Date:    2011 Oct-Dec
Date Detail:
Created Date:  2012-01-02     Completed Date:  2012-05-08     Revised Date:  2013-06-17    
Medline Journal Info:
Nlm Unique ID:  9802544     Medline TA:  Ann Transplant     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  7-11     Citation Subset:  IM    
Department of Transplant Surgery, Jichi Medical University,3311-1 Yakushiji,Shimotsuke City, Tochigi, Japan.
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MeSH Terms
Biliary Atresia / complications*,  surgery*
Child, Preschool
Esophageal and Gastric Varices / complications,  surgery
Gastrointestinal Hemorrhage / complications,  surgery
Hypertension, Portal / complications*,  surgery*
Jaundice / complications
Liver Transplantation* / adverse effects,  methods
Living Donors
Postoperative Complications / etiology
Young Adult

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