Document Detail

Indiacens A and B: Prenyl Indoles from the Myxobacterium Sandaracinus amylolyticus.
MedLine Citation:
PMID:  23035772     Owner:  NLM     Status:  Publisher    
The gliding bacterium Sandaracinus amylolyticus, strain NOSO-4T, was recently characterized as the first representative of a new myxobacterial genus. A screening of the culture broth for antibiotically active metabolites followed by isolation and characterization revealed two unique 3-formylindol derivatives, indiacen A (1) and its chloro derivative indiacen B (2). Both are active against Gram-positive and Gram-negative bacteria as well as the fungus Mucor hiemalis. The biosynthetic origin of the isoprene-like side chain in 1 and 2 was studied by in vivo feeding experiments with (13)C-labeled precursors.
Heinrich Steinmetz; Kathrin I Mohr; Wiebke Zander; Rolf Jansen; Klaus Gerth; Rolf Müller
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Journal of natural products     Volume:  -     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Research Group Microbial Drugs, Helmholtz Centre for Infection Research , Inhoffenstrasse 7, 38124 Braunschweig, Germany.
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