Document Detail


Independently regulated neocentromere activity of two classes of tandem repeat arrays.
MedLine Citation:
PMID:  11884683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tandem repeat arrays often are found in interstitial (i.e., normally gene-rich) regions on chromosomes. In maize, genes on abnormal chromosome 10 induce the tandem repeats that make up knobs to move poleward on the meiotic spindle. This so-called neocentromere activity results in the preferential recovery, or meiotic drive, of the knobs in progeny. Here we show that two classes of repeats differ in their capacity to form neocentromeres and that their motility is controlled in trans by at least two repeat-specific activators. Microtubule dynamics appear to contribute little to the movement of neocentromeres (they are active in the presence of taxol), suggesting that the mechanism of motility involves microtubule-based motors. These data suggest that maize knob repeats and their binding proteins have coevolved to ensure their preferential recovery in progeny. Neocentromere-mediated drive provides a plausible mechanism for the evolution and maintenance of repeat arrays that occur in interstitial positions.
Authors:
Evelyn N Hiatt; Edward K Kentner; R Kelly Dawe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Plant cell     Volume:  14     ISSN:  1040-4651     ISO Abbreviation:  Plant Cell     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-08     Completed Date:  2002-06-20     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  9208688     Medline TA:  Plant Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  407-20     Citation Subset:  IM    
Affiliation:
Department of Genetics, University of Georgia, Athens, Georgia 30602, USA.
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MeSH Terms
Descriptor/Qualifier:
Carrier Proteins / genetics
Centromere / genetics,  metabolism*
Chromosome Aberrations
Gene Expression Regulation, Plant / drug effects
In Situ Hybridization
Meiosis / genetics
Microtubules / physiology
Paclitaxel / pharmacology
Plant Structures / drug effects,  genetics
Tandem Repeat Sequences / genetics*
Zea mays / genetics*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 33069-62-4/Paclitaxel
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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