Document Detail

Independent role of blood pressure on cardiovascular risk factors in nondiabetic, obese African-American women with family history of type 2 diabetes: Implications for metabolic syndrome components.
MedLine Citation:
PMID:  20409942     Owner:  NLM     Status:  PubMed-not-MEDLINE    
African-American women (AAW) suffer disproportionately from hypertension and its consequences. We investigated the significance of systolic and diastolic blood pressure (SBP/DBP) as components of metabolic syndrome (MetS) in nondiabetic, overweight/obese AAW. We studied 258 AAW (mean age, 42.4 +/- 8.4 years and body mass index (BMI), 33.4 +/- 8.0 kg/m(2)) in a cross-sectional manner. We estimated the prevalence of MetS and its components using Adult Treatment Panel (ATP III) criteria, insulin sensitivity (Si), insulin resistance (HOMA-IR), and cardiovascular disease risk factors according to the tertiles of blood pressure (BP). Mean age and BMI did not differ with increases in BP tertiles. At screening, 35.7% of our subjects were hypertensive. MetS was found in 32.2% of our AAW. Prevalence of MetS increased as the tertiles of BP increased (SBP = first [10.5%], second [15.1%], third [58.1%], and DBP = first [9.3%], second [23.3%], third [54.7%]). We found that the components of Adult Treatment Panel (ATP) did not track with the corresponding BP tertiles. However, the prevalence of individuals meeting ATP III criteria for BP was highest in the third tertile of both SBP and DBP. Consequently, the prevalence of MetS was highest in the third vs. first and second tertiles. Using linear regression analysis, SBP and DBP did not correlate with the conventional cardiovascular risk factors, HOMA-IR, or Si. In overweight/obese AAW, we found the components of MetS do not track with BP. In the absence of elevated BP, the prevalence of MetS appears to be very low in overweight and obese AAW. Conversely, elevated BP or hypertension was associated with remarkably higher rates of MetS in our AAW. Therefore BP criteria constitute an important and independent determinant of ATP III definition of MetS in AAW.
Trudy Gaillard; Dara Schuster; Kwame Osei
Publication Detail:
Type:  Journal Article     Date:  2008-10-31
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  3     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2010-04-22     Completed Date:  2012-10-02     Revised Date:  2012-10-29    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-34     Citation Subset:  -    
Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University, Columbus, Ohio, USA.
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