| Independent prediction of metabolic syndrome by plasma fibrinogen in men, and predictors of elevated levels. | |
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MedLine Citation:
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PMID: 18582961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of plasma fibrinogen levels in predicting metabolic syndrome (MetS) and assessment of determinants of these levels were investigated. A total of 2234 men and women, aged 49+/-12 years, representative of Turkish adults who had plasma fibrinogen determinations, were prospectively evaluated and followed for a mean of 6.6 years. The modified Clauss method was used for assays. MetS was defined by ATPIII criteria modified for male abdominal obesity. MetS cases at baseline were excluded in prospective analyses. Median (interquartile range) fibrinogen values were 2.87 (2.29; 3.56) g/L. Fibrinogen levels predicted significantly newly developing MetS in men (RR 1.40 [95%CI 1.07; 1.83] for a 2-fold increment), after adjustment for age and smoking status, and (RR 1.32 [95%CI 0.95; 1.83] again for doubling), after additional adjustment for all 5 components of MetS. MetS was not significantly predicted by fibrinogen levels in women in either multivariable model. By regression analysis of eight covariates, not waist circumference, but systolic blood pressure, current smoking and C-reactive protein (CRP) in men, and age in women were predictors of elevated (>3.0 g/L) fibrinogen at follow-up (p<0.05 in all). CONCLUSIONS: Plasma fibrinogen predicts MetS independently of its components in men, in contradistinction to women, and, hence, is likely one of its components. Hyperfibrinogenemia representing an inflammatory state is postulated as the underlying mechanism. Central obesity is linked to elevation in fibrinogen mainly through the mediation of blood pressure, CRP, and via being affected by cigarette smoking. |
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Authors:
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Altan Onat; Hakan Ozhan; Enver Erbilen; Sinan Albayrak; Zekeriya Küçükdurmaz; Günay Can; Ibrahim Keleş; Gülay Hergenç |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-25 |
Journal Detail:
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Title: International journal of cardiology Volume: 135 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-15 Completed Date: 2009-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 211-7 Citation Subset: IM |
Affiliation:
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Turkish Society of Cardiology, Istanbul University, Turkey. alt_onat@yahoo.com.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure C-Reactive Protein / metabolism Female Fibrinogen / metabolism* Humans Insulin Resistance Male Metabolic Syndrome X / blood*, epidemiology* Middle Aged Multivariate Analysis Obesity / blood, epidemiology Predictive Value of Tests Prospective Studies Risk Factors Sex Distribution Smoking / blood, epidemiology Turkey / epidemiology |
| Chemical | |
Reg. No./Substance:
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9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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