| Independent and incremental prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging in coronary artery disease. | |
| | |
MedLine Citation:
|
PMID: 8354796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: The objective of this study was to examine the independent and incremental prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging in patients with angiographically defined coronary artery disease. BACKGROUND: Previous studies showed the importance of exercise thallium-201 in risk stratification. However, most of these studies used planar imaging techniques. METHODS: Follow-up data were obtained in 316 medically treated patients with coronary artery disease. Cox proportional hazards regression models were used to examine the independent and incremental prognostic values of clinical, exercise, thallium and cardiac catheterization data. RESULTS: There were 35 events (cardiac death or nonfatal myocardial infarction) at a mean follow-up time of 28 months. Univariate analysis showed that gender (chi-square = 5.1), exercise work load (chi-square = 3.1), extent of coronary artery disease and left ventricular ejection fraction (chi-square = 14.8) and thallium variables (chi-square = 22.7) were prognostically important. The thallium data provided incremental prognostic value to catheterization data (chi-square = 33.7, p < 0.01). The extent of the perfusion abnormality was the single best predictor of prognosis (chi-square = 14). Patients with a large perfusion abnormality had a worse prognosis than that of patients with a mild or no abnormality (Mantel-Cox statistics = 10.6, p < 0.001). CONCLUSIONS: In medically treated patients with coronary artery disease, exercise SPECT thallium imaging provides independent and incremental prognostic information even when catheterization data are available. The extent of the perfusion abnormality is the single most important prognostic predictor. |
| | |
Authors:
|
A S Iskandrian; S C Chae; J Heo; C D Stanberry; V Wasserleben; V Cave |
Related Documents
:
|
16899176 - Gated spect myocardial perfusion scintigraphy for identifying septal perfusion artifact... 7431646 - Quantitative analysis of thallium-201 uptake and the effect of heart rate. 17577676 - A comparative evaluation of tl-201 and tc-99m sestamibi myocardial perfusion spect imag... 9858296 - Tl-201 myocardial spect in patients with systemic arterial diseases. 8025136 - Controversies in myocardial revascularization: coronary artery surgery for single-vesse... 17134776 - The straight wire sign: recognizing guidewire exit during percutaneous coronary interve... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 22 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1993 Sep |
Date Detail:
|
Created Date: 1993-09-23 Completed Date: 1993-09-23 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 665-70 Citation Subset: AIM; IM |
Affiliation:
|
Philadelphia Heart Institute, Presbyterian Medical Center, Pennsylvania 19104. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Chi-Square Distribution Coronary Angiography Coronary Disease / mortality, radionuclide imaging* Exercise Test* / methods, statistics & numerical data Female Follow-Up Studies Heart Catheterization / statistics & numerical data Humans Male Middle Aged Prognosis Proportional Hazards Models Survival Analysis Thallium Radioisotopes / diagnostic use* Tomography, Emission-Computed, Single-Photon* / methods, statistics & numerical data |
| Chemical | |
Reg. No./Substance:
|
0/Thallium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Abnormal systolic blood pressure response during exercise recovery in patients with angina pectoris.
Next Document: Ischemic threshold during two exercise testing protocols and during ambulatory electrocardiographic ...