Document Detail


Independent and incremental prognostic value of endogenous ouabain in idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  16188497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased circulating levels of endogenous ouabain (EO) have been observed in some heart failure patients, but their long term clinical significance is unknown. This study investigated the prognostic value of EO for worsening heart failure among 140 optimally treated patients (age 50+/-14 years; 104 male; NYHA class 1.9+/-0.7) with idiopathic dilated cardiomyopathy. Plasma EO was determined by RIA and by liquid chromatography mass spectrometry, values were linearly correlated (r = 0.89) in regression analysis. During follow-up (13+/-5 months), heart failure progression was defined as worsening clinical condition leading to one or more of the following: sustained increase in conventional therapies, hospitalization, cardiac transplant, or death. NYHA functional class, age, LVEF, peak VO2 and plasma levels of EO were predictive for heart failure progression. Heart failure worsened 1.5 fold (HR: 1.005; 95% CI: 1.001-1.007; p<0.01) for each 100 pmol/L increase in plasma EO. Moreover, those patients with higher plasma EO values had an odds ratio of 5.417 (95% CI: 2.044-14.355; p<0.001) for heart failure progression. Following multivariate analysis, LVEF, NYHA class and plasma EO remained significantly linked with clinical events. This study provides the first evidence that circulating EO is a novel, independent and incremental marker that predicts the progression of heart failure.
Authors:
Maria Vittoria Pitzalis; John M Hamlyn; Elisabetta Messaggio; Massimo Iacoviello; Cinzia Forleo; Roberta Romito; Elisabetta de Tommasi; Paolo Rizzon; Giuseppe Bianchi; Paolo Manunta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-09-26
Journal Detail:
Title:  European journal of heart failure     Volume:  8     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-20     Completed Date:  2007-12-13     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  IM    
Affiliation:
Institute of Cardiology, University of Bari, Bari, Italy.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Cardiomyopathy, Dilated / blood*
Case-Control Studies
Disease Progression
Exercise Test
Female
Humans
Male
Mass Spectrometry
Middle Aged
Ouabain / blood*
Oxygen Consumption
Prognosis
Prospective Studies
Radioimmunoassay
Regression Analysis
Stroke Volume
Grant Support
ID/Acronym/Agency:
HL075584/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
630-60-4/Ouabain

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