| Independent and incremental prognostic value of endogenous ouabain in idiopathic dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 16188497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased circulating levels of endogenous ouabain (EO) have been observed in some heart failure patients, but their long term clinical significance is unknown. This study investigated the prognostic value of EO for worsening heart failure among 140 optimally treated patients (age 50+/-14 years; 104 male; NYHA class 1.9+/-0.7) with idiopathic dilated cardiomyopathy. Plasma EO was determined by RIA and by liquid chromatography mass spectrometry, values were linearly correlated (r = 0.89) in regression analysis. During follow-up (13+/-5 months), heart failure progression was defined as worsening clinical condition leading to one or more of the following: sustained increase in conventional therapies, hospitalization, cardiac transplant, or death. NYHA functional class, age, LVEF, peak VO2 and plasma levels of EO were predictive for heart failure progression. Heart failure worsened 1.5 fold (HR: 1.005; 95% CI: 1.001-1.007; p<0.01) for each 100 pmol/L increase in plasma EO. Moreover, those patients with higher plasma EO values had an odds ratio of 5.417 (95% CI: 2.044-14.355; p<0.001) for heart failure progression. Following multivariate analysis, LVEF, NYHA class and plasma EO remained significantly linked with clinical events. This study provides the first evidence that circulating EO is a novel, independent and incremental marker that predicts the progression of heart failure. |
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Authors:
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Maria Vittoria Pitzalis; John M Hamlyn; Elisabetta Messaggio; Massimo Iacoviello; Cinzia Forleo; Roberta Romito; Elisabetta de Tommasi; Paolo Rizzon; Giuseppe Bianchi; Paolo Manunta |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2005-09-26 |
Journal Detail:
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Title: European journal of heart failure Volume: 8 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-20 Completed Date: 2007-12-13 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 179-86 Citation Subset: IM |
Affiliation:
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Institute of Cardiology, University of Bari, Bari, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Cardiomyopathy, Dilated / blood* Case-Control Studies Disease Progression Exercise Test Female Humans Male Mass Spectrometry Middle Aged Ouabain / blood* Oxygen Consumption Prognosis Prospective Studies Radioimmunoassay Regression Analysis Stroke Volume |
| Grant Support | |
ID/Acronym/Agency:
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HL075584/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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630-60-4/Ouabain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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