| Independent cytotoxic and inflammatory responses to zinc oxide nanoparticles in human monocytes and macrophages. | |
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MedLine Citation:
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PMID: 22087559 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Significant public and scientific concerns remain for the use of nanoparticles (NPs) in commercial products, particularly those applied topically for skin care. There are currently a range of metal oxides formulated into many sunscreens that are present at the nanoscale. In this study, we sought to determine the effect of the size and dispersion of one type of these NPs (zinc oxide) on immune cell function and cytotoxicity for human macrophages and monocytes, which are key cells for particle and debris clearance in the skin. We have found that particle size and coating, but surprisingly, not agglomeration, are key determinates of nanoparticle cytotoxicity in an in vitro culture system of human immune cells. Most importantly, we found that this nanoparticle-induced cellular immune signalling, can be decoupled from cytotoxicity and surface coating, so that at an equivalent cytotoxic load, smaller particles induce a greater cellular response. |
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Authors:
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Bryce N Feltis; Sean J O'Keefe; Andrew J Harford; Terrence J Piva; Terence W Turney; Paul F A Wright |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-17 |
Journal Detail:
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Title: Nanotoxicology Volume: - ISSN: 1743-5404 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233132 Medline TA: Nanotoxicology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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RMIT University, School of Medical Sciences, Bundoora, Victoria , Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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