Document Detail


Independent component analysis of normal and abnormal rhythm in twin pregnancies.
MedLine Citation:
PMID:  21098910     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the utility of ICA for evaluation of fetal rhythm in five uncomplicated twin pregnancies and in five twin pregnancies complicated by fetal arrhythmia. Using objective and subjective criteria, we sought to determine how the signal-to-noise ratio, signal fidelity and interference rejection are affected when synthesizing the fetal signal using all the signal-containing ICA components (rank-p ICA) versus using the single dominant component (rank-1 ICA). The signal of each fetus was most commonly distributed over 1 or 2 ICA components, as previously observed in studies of singleton pregnancies; however, in 8 of 26 (31%) cases the signal of each fetus was distributed over 3, 4 or even 5 ICA components. Rank-1 ICA provided the highest SNR and interference rejection, but at the cost of reduced signal fidelity. Our results corroborate that in twin pregnancies, including twin pregnancies complicated by fetal arrhythmia, rank-1 ICA is very effective in isolating the QRS complexes of each fetus; however, it has some limitations when used for fetal rhythm evaluation due to signal distortion. Occasionally, rank-1 ICA completely separates the P-wave and the T-wave from the QRS complex, thus requiring the mixing of several ICA components to achieve acceptable signal fidelity.
Authors:
Nana Aba Mensah-Brown; William J Lutter; Silvia Comani; Janette F Strasburger; Ronald T Wakai
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-11-19
Journal Detail:
Title:  Physiological measurement     Volume:  32     ISSN:  1361-6579     ISO Abbreviation:  Physiol Meas     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-07-14     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  England    
Other Details:
Languages:  eng     Pagination:  51-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Echocardiography / methods*
Female
Heart Rate, Fetal / physiology*
Humans
Pregnancy
Pregnancy, Multiple / physiology*
Twins
Ultrasonography, Prenatal
Grant Support
ID/Acronym/Agency:
R01 HL063174/HL/NHLBI NIH HHS; R01 HL063174-10/HL/NHLBI NIH HHS; R01-HL063174/HL/NHLBI NIH HHS
Comments/Corrections

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