Document Detail


Independent and combined influence of AGTR1 variants and aerobic exercise on oxidative stress in hypertensives.
MedLine Citation:
PMID:  19593696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abstract Angiotensin II (AngII), via the AngII type 1 receptor (AT(1)R), contributes to oxidative stress. Aerobic exercise training (AEXT) reduces the risk of cardiovascular (CV) disease, presumably by reducing the grade of oxidative stress. We investigated the independent and combined influence of the AGTR1 A1166C and -825 T/A polymorphisms on oxidative stress and plasma AngII responses to AEXT in pre- and stage 1 hypertensives. Urinary 8-iso-PGF(2alpha) significantly increased with AEXT (p=0.002); however, there were no significant changes in superoxide dismutase activity or AngII levels. There was a significant difference in the change in AngII levels with AEXT between A1166C genotype groups (p=0.04) resulting in a significant interactive effect of the A1166C polymorphism and AEXT on the change in AngII (p<0.05). Only the TT genotype group of the -825 T/A polymorphism had a significant reduction in plasma AngII (p=0.02). Risk allele analysis revealed a significant reduction in plasma AngII (p=0.04) and a significant increase in urinary 8-iso-PGF(2alpha) (p=0.01) with AEXT in individuals with two risk alleles only. Our findings suggest that variation in the AGTR1 gene is associated with differential changes in plasma AngII but not oxidative stress.
Authors:
Nicola Fenty-Stewart; Joon-Young Park; Stephen M Roth; James M Hagberg; Samar Basu; Robert E Ferrell; Michael D Brown
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  18     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2009  
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-12-27     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  204-12     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD, USA. nicola.fenty@temple.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Alleles
Angiotensin II / blood,  genetics
Blood Pressure / drug effects,  genetics
Exercise / physiology*
Female
Genotype
Humans
Hypertension / blood,  genetics*,  metabolism*
Male
Middle Aged
Oxidative Stress / genetics*
Polymorphism, Genetic
Receptor, Angiotensin, Type 1 / genetics*,  metabolism
Grant Support
ID/Acronym/Agency:
AG00268/AG/NIA NIH HHS; AG022791/AG/NIA NIH HHS; AG15384/AG/NIA NIH HHS; AG17474/AG/NIA NIH HHS; K01 AG019640-05/AG/NIA NIH HHS; KO1AG19640/AG/NIA NIH HHS; R01 HL085497-01A1/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/AGTR1 protein, human; 0/Receptor, Angiotensin, Type 1; 11128-99-7/Angiotensin II
Comments/Corrections

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