Document Detail


Independent circadian and sleep/wake regulation of adipokines and glucose in humans.
MedLine Citation:
PMID:  15687326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leptin and adiponectin play important physiological roles in regulating appetite, food intake, and energy balance and have pathophysiological roles in obesity and anorexia nervosa. To assess the relative contributions of day/night patterns in behaviors (sleep/wake cycle and food intake) and of the endogenous circadian pacemaker on observed day/night patterns of adipokines, in six healthy subjects we measured circulating leptin, soluble leptin receptor, adiponectin, glucose, and insulin levels throughout a constant routine protocol (38 h of wakefulness with constant posture, temperature, and dim light, as well as identical snacks every 2 h) and throughout sleep and fasting periods before and after the constant routine. There were significant endogenous circadian rhythms in leptin, glucose, and insulin, with peaks around the usual time of awakening. Sleep/fasting resulted in additional systematic decreases in leptin, glucose, and insulin, whereas wakefulness/food intake resulted in a systematic increase in leptin. Thus, the day/night pattern in leptin is likely caused by combined effects from the endogenous circadian pacemaker and day/night patterns in behaviors. Our data imply that alterations in the sleep/wake schedule would lead to an increased daily range in circulating leptin, with lowest leptin upon awakening, which, by influencing food intake and energy balance, could be implicated in the increased prevalence of obesity in the shift work population.
Authors:
Steven A Shea; Michael F Hilton; Christine Orlova; R Timothy Ayers; Christos S Mantzoros
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2005-02-01
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  90     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-05     Completed Date:  2005-06-09     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2537-44     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adiponectin
Adult
Blood Glucose / analysis
Circadian Rhythm*
Humans
Insulin / blood
Intercellular Signaling Peptides and Proteins / blood*
Leptin / blood*
Male
Middle Aged
Obesity / etiology
Sleep / physiology*
Wakefulness / physiology*
Work Schedule Tolerance
Grant Support
ID/Acronym/Agency:
K24 HL076446-05/HL/NHLBI NIH HHS; K24 HL76446/HL/NHLBI NIH HHS; M01 RR02635/RR/NCRR NIH HHS; R01 57875//PHS HHS; R01 HL064815-04/HL/NHLBI NIH HHS; R01 HL076409-03/HL/NHLBI NIH HHS; R01 HL64815/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Blood Glucose; 0/Insulin; 0/Intercellular Signaling Peptides and Proteins; 0/Leptin
Comments/Corrections

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