Document Detail

Independent activation of hepatitis B virus biosynthesis by retinoids, peroxisome proliferators, and bile acids.
MedLine Citation:
PMID:  23135717     Owner:  NLM     Status:  MEDLINE    
In the human hepatoma cell line HepG2, retinoic acid, clofibric acid, and bile acid treatment can only modestly increase hepatitis B virus (HBV) biosynthesis. Utilizing the human embryonic kidney cell line 293T, it was possible to demonstrate that the retinoid X receptor α (RXRα) plus its ligand can support viral biosynthesis independently of additional nuclear receptors. In addition, RXRα/peroxisome proliferator-activated receptor α (PPARα) and RXRα/farnesoid X receptor α (FXRα) heterodimeric nuclear receptors can also mediate ligand-dependent HBV transcription and replication when activated by clofibric acid and bile acid, respectively, independently of a requirement for the ligand-dependent activation of RXRα. These observations indicate that there are at least three possible modes of ligand-mediated activation of HBV transcription and replication existing within hepatocytes, suggesting that multiple independent mechanisms control viral production in the livers of infected individuals.
Vanessa C Reese; Claudia E Oropeza; Alan McLachlan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-07
Journal Detail:
Title:  Journal of virology     Volume:  87     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-28     Completed Date:  2013-02-25     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  991-7     Citation Subset:  IM    
Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
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MeSH Terms
Bile Acids and Salts / metabolism*
Cell Line
Epithelial Cells / drug effects,  virology
Hepatitis B virus / drug effects*,  physiology*
Hepatocytes / drug effects,  virology
Peroxisome Proliferators / metabolism*
Retinoids / metabolism*
Transcription, Genetic
Transcriptional Activation / drug effects*
Virus Replication / drug effects*
Grant Support
Reg. No./Substance:
0/Bile Acids and Salts; 0/Peroxisome Proliferators; 0/Retinoids

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