| Independent activation of hepatitis B virus biosynthesis by retinoids, peroxisome proliferators, and bile acids. | |
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MedLine Citation:
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PMID: 23135717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the human hepatoma cell line HepG2, retinoic acid, clofibric acid, and bile acid treatment can only modestly increase hepatitis B virus (HBV) biosynthesis. Utilizing the human embryonic kidney cell line 293T, it was possible to demonstrate that the retinoid X receptor α (RXRα) plus its ligand can support viral biosynthesis independently of additional nuclear receptors. In addition, RXRα/peroxisome proliferator-activated receptor α (PPARα) and RXRα/farnesoid X receptor α (FXRα) heterodimeric nuclear receptors can also mediate ligand-dependent HBV transcription and replication when activated by clofibric acid and bile acid, respectively, independently of a requirement for the ligand-dependent activation of RXRα. These observations indicate that there are at least three possible modes of ligand-mediated activation of HBV transcription and replication existing within hepatocytes, suggesting that multiple independent mechanisms control viral production in the livers of infected individuals. |
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Authors:
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Vanessa C Reese; Claudia E Oropeza; Alan McLachlan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-11-07 |
Journal Detail:
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Title: Journal of virology Volume: 87 ISSN: 1098-5514 ISO Abbreviation: J. Virol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-28 Completed Date: 2013-02-25 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 991-7 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bile Acids and Salts
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metabolism* Cell Line Epithelial Cells / drug effects, virology Hepatitis B virus / drug effects*, physiology* Hepatocytes / drug effects, virology Humans Peroxisome Proliferators / metabolism* Retinoids / metabolism* Transcription, Genetic Transcriptional Activation / drug effects* Virus Replication / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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AI081451/AI/NIAID NIH HHS; AI30070/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Peroxisome Proliferators; 0/Retinoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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