| Independence of hypoxic death of inspiratory PCO2 in rats and fossorial mole rats. | |
| | |
MedLine Citation:
|
PMID: 6438855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Laboratory white rats and fossorial mole rats (Spalax ehrenbergi) were subjected to progressive hypoxia by enclosure in a thermoregulated, confined atmosphere. Variable levels of environmental CO2 were obtained by controlling the duration of CO2 absorbance. Rats had preimplanted electroencephalographic (EEG) and electrocardiographic (EKG) electrodes and a rectal temperature probe. Animals were followed until their last gasp and EEG flattening, at which time the chamber's atmosphere was analyzed. The mole rat demonstrated a significantly lower terminal PIO2 [20.9 +/- 3.5 (SD) vs. 38.0 +/- 8.4 (SD) Torr]; however, in both animals terminal PIO2 was independent of PICO2 over a range of the latter of 0-117 Torr. Rats showed a progressive decline in rectal temperature from a PIO2 of 80 Torr on, amounting finally to 2.3 degrees C. The rats' oxygen consumption was maintained down to a PIO2 of 65 Torr and declined from then on. A group of rats with maximal CO2 accumulation showed a greater decline of rectal temperature and a steeper drop of VO2 with respect to PO2 compared to a group with no CO2 buildup. The main result was unexpected, in view of the theoretical synergism of the adverse effects of hypoxia and hypercapnia, and should reorient current thinking on survival and resuscitation in confined spaces. |
| | |
Authors:
|
R Arieli; D Kerem |
Related Documents
:
|
11538835 - Temperature effects on evoked potentials of hippocampal slices from euthermic chipmunks... 17430625 - Acclimatization of rats after ground transportation to a new animal facility. 11238815 - The influence of heating on the anticancer properties of garlic. 17928015 - The energetics of huddling in two species of mole-rat (rodentia: bathyergidae). 8094735 - Antibodies to intercellular adhesion molecule 1/lymphocyte function-associated antigen ... 6662205 - Urea formation in rat, bovine, and human lens. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Undersea biomedical research Volume: 11 ISSN: 0093-5387 ISO Abbreviation: Undersea Biomed Res Publication Date: 1984 Sep |
Date Detail:
|
Created Date: 1985-01-18 Completed Date: 1985-01-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0421514 Medline TA: Undersea Biomed Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 275-85 Citation Subset: IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anoxia / etiology*, physiopathology Body Temperature Carbon Dioxide* Cardiac Output Female Male Pulmonary Gas Exchange* Rats Respiration Rodentia |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Amino acid composition of proteoglycan protein of human articular cartilage in normal conditions and...
Next Document: Intravesical and systemic chemotherapy in the management of superficial bladder cancer.