Document Detail

Incubation of conditioned fear in the conditioned suppression model in rats: role of food-restriction conditions, length of conditioned stimulus, and generality to conditioned freezing.
MedLine Citation:
PMID:  20600654     Owner:  NLM     Status:  MEDLINE    
We recently adapted the conditioned suppression of operant responding method to study fear incubation. We found that food-restricted rats show low fear 2 days after extended (10 d; 100 30-s tone-shock pairings) fear training and high fear after 1-2 months. Here, we studied a potential mechanism of fear incubation: extended food-restriction stress. We also studied whether fear incubation is observed after fear training with a prolonged-duration (6-min) tone conditioned stimulus (CS), and whether conditioned freezing incubates after extended training in rats with or without a concurrent operant task. Conditioned fear was assessed 2 days and 1 month after training. In the conditioned suppression method, fear incubation was reliably observed in rats under moderate food-restriction conditions (18-20 g food/day) that allowed for weight gain, and after extended (10 d), but not limited (1 d), fear training with the 6-min CS. Incubation of conditioned freezing was observed after extended fear training in rats lever-pressing for food and, to a lesser degree, in rats not performing an operant task. Results indicate that prolonged hunger-related stress does not account for fear incubation in the conditioned suppression method, and that fear incubation occurs to a longer-duration (6-min) fear CS. Extended training also leads to robust fear incubation of conditioned freezing in rats performing an operant task and weaker fear incubation in rats not performing an operant task.
C L Pickens; B M Navarre; S G Nair
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2010-06-22
Journal Detail:
Title:  Neuroscience     Volume:  169     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2011-04-18     Revised Date:  2012-04-26    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1501-10     Citation Subset:  IM    
Copyright Information:
(c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Behavioral Neuroscience Branch, Intramural Research Program-National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21218, USA.
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MeSH Terms
Conditioning (Psychology) / physiology*
Disease Models, Animal
Ethology / methods*
Fear / physiology*
Food Deprivation / physiology*
Neuropsychology / methods*
Rats, Long-Evans
Stress, Psychological / etiology,  physiopathology,  psychology*
Grant Support

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