Document Detail


Incubation of conditioned fear in the conditioned suppression model in rats: role of food-restriction conditions, length of conditioned stimulus, and generality to conditioned freezing.
MedLine Citation:
PMID:  20600654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We recently adapted the conditioned suppression of operant responding method to study fear incubation. We found that food-restricted rats show low fear 2 days after extended (10 d; 100 30-s tone-shock pairings) fear training and high fear after 1-2 months. Here, we studied a potential mechanism of fear incubation: extended food-restriction stress. We also studied whether fear incubation is observed after fear training with a prolonged-duration (6-min) tone conditioned stimulus (CS), and whether conditioned freezing incubates after extended training in rats with or without a concurrent operant task. Conditioned fear was assessed 2 days and 1 month after training. In the conditioned suppression method, fear incubation was reliably observed in rats under moderate food-restriction conditions (18-20 g food/day) that allowed for weight gain, and after extended (10 d), but not limited (1 d), fear training with the 6-min CS. Incubation of conditioned freezing was observed after extended fear training in rats lever-pressing for food and, to a lesser degree, in rats not performing an operant task. Results indicate that prolonged hunger-related stress does not account for fear incubation in the conditioned suppression method, and that fear incubation occurs to a longer-duration (6-min) fear CS. Extended training also leads to robust fear incubation of conditioned freezing in rats performing an operant task and weaker fear incubation in rats not performing an operant task.
Authors:
C L Pickens; B M Navarre; S G Nair
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2010-06-22
Journal Detail:
Title:  Neuroscience     Volume:  169     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2011-04-18     Revised Date:  2012-04-26    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1501-10     Citation Subset:  IM    
Copyright Information:
(c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Behavioral Neuroscience Branch, Intramural Research Program-National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21218, USA. pickensc@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning (Psychology) / physiology*
Disease Models, Animal
Ethology / methods*
Fear / physiology*
Food Deprivation / physiology*
Male
Neuropsychology / methods*
Rats
Rats, Long-Evans
Stress, Psychological / etiology,  physiopathology,  psychology*
Grant Support
ID/Acronym/Agency:
Z99 DA999999/DA/NIDA NIH HHS
Comments/Corrections

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