| The Incubation of 13a,17-Dihydroxystemodane with Cephalosporium aphidicola. | |
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MedLine Citation:
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PMID: 22322449 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The biotransformation of 13a,17-dihydroxystemodane (3) with the fungus Cephalosporium aphidicola afforded 13a,17,18-trihydroxystemodane (4), 3b,13a,17-tri-hydroxystemodane (5), 13a,17-dihydroxy-stemodan-18-oic acid (6), 3b,11β,13a,17-tetra-hydroxystemodane (7), 11β,13a,17,18-tetrahydroxystemodane (8) and 3b,13a,17,18-tetra-hydroxystemodane (9). The hydroxylation at C-18 of the substrate points to a biosynthetically-directed transformation, because aphidicolin (2) is hydroxylated at this carbon. However, the C-3(b) and C-11(b) hydroxylations seem to indicate a xenobiotic biotransformation. |
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Authors:
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Braulio M Fraga; Ricardo Guillermo; Melchor G Hernández; María C Chamy; Juan A Garbarino |
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Publication Detail:
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Type: Journal Article Date: 2012-02-09 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 17 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1744-50 Citation Subset: IM |
Affiliation:
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Instituto de Productos Naturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez 3, La Laguna, Tenerife, Canary Islands, 38206, Spain. bmfraga@ipna.csic.es. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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