Document Detail

Increments in whole body bone mineral content associated with weight and length in pre-term and full-term infants during the first 6 months of life.
MedLine Citation:
PMID:  11440785     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objective of the present study was to assess bone mineral content (BMC) of the whole skeleton in pre-term and full-term healthy infants and the factors influencing BMC, such as bone area, birth weight, birth length, current weight, current length, gender, and gestational age. METHODS: Forty-eight healthy full-term infants and 34 healthy premature infants fed predominantly with intact human milk were studied. BMC was measured monthly with dual energy X-ray absorptiometry (DEXA). At the same time, length and weight were measured and registered. Pre-term infants were studied at 60-day intervals. RESULTS: For both full-term and pre-term infants, BMC increased during the first months of life. However, the values of pre-term infants never reached the values of full-term infants, even after correcting for age and weight. For both full-term and pre-term infants, BMC was significantly correlated at the second month with birth weight (r = 0.901), birth length (r = 0.860), gestational age (r = 0.803), bone area (r = 0.960), current weight (r = 0.920), and current length (r = 0.840, p <0.001 for all correlation coefficients). Multivariate analysis revealed that bone area was the most important factor in predicting BMC. CONCLUSIONS: Pre-term children have lower BMC than full-term children. The main factor explaining this apparent osteopenia is bone area. Pre-term children have a higher daily mineralization rate than full-term children, but this catch-up mineralization is not enough to reach BMC levels seen in full-term children.
M Avila-Díaz; S Flores-Huerta; I Martínez-Muñiz; D Amato
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of medical research     Volume:  32     ISSN:  0188-4409     ISO Abbreviation:  Arch. Med. Res.     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-07-06     Completed Date:  2001-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  288-92     Citation Subset:  IM    
Unidad de Investigación Médica en Nutrición Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
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MeSH Terms
Absorptiometry, Photon
Birth Weight
Body Height
Body Weight
Bone Density / physiology*
Bone Development / physiology*
Bone Diseases, Metabolic / congenital*
Breast Feeding
Calcium / analysis
Follow-Up Studies
Infant, Low Birth Weight / growth & development*
Infant, Newborn / growth & development*
Infant, Premature / growth & development*
Osteogenesis / physiology*
Reference Values
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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