| Incremental value of left ventricular diastolic function reserve index for predicting exercise capacity in patients with hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 17904804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The changes of left ventricular diastolic function during exercise are heterogeneous in patients with hypertrophic cardiomyopathy (HCM). We sought to investigate whether exertional changes of mitral annular velocities and plasma N-terminal-pro-B-type natriuretic peptide (BNP) concentration are associated with exercise capacity in patients with HCM. After a comprehensive echocardiographic study, 32 patients with HCM performed symptom-limited graded supine bicycle exercise. Echocardiographic Doppler parameters were measured at each stage of exercise. Blood samples were collected at rest and immediately after exercise to determine the concentration of pro-BNP. Resting pro-BNP (r = -0.620, P < .001), E'(base) (r = 0.414, P = .018), and DeltaE'(50W) (change of E' from base to 50 W of exercise) (r = 0.367, P = .039) were significantly correlated with exercise duration. Left ventricular longitudinal diastolic function reserve index, defined as DeltaE' x E'(base), significantly correlated with exercise duration (at 50 W, r = 0.540, P = .001) independent of age, sex, body mass index, and resting pro-BNP level. When combining DeltaE' x E'(50W) (<5.85 cm(2)/s(2)) and resting pro-BNP (>740 mg/dL), the predictive accuracy for exercise capacity could be improved (for <500 seconds, global chi(2) = 5.84 in pro-BNP vs 8.10 in pro-BNP + DeltaE' x E'(50W), P = .023). The assessment of left ventricular longitudinal diastolic function reserve can provide incremental information to pro-BNP for the prediction of exercise capacity in patients with HCM. |
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Authors:
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Eui-Young Choi; Jong-Won Ha; Se-Joong Rim; Sung-Ai Kim; Se-Jung Yoon; Chi-Young Shim; Jin-Mi Kim; Yangsoo Jang; Namsik Chung; Seung-Yun Cho |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-29 |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 21 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-05 Completed Date: 2008-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 487-92 Citation Subset: IM |
Affiliation:
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Cardiology Division, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiomyopathy, Hypertrophic
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blood,
complications,
ultrasonography* Echocardiography / methods* Exercise Test Exercise Tolerance* Female Fractional Flow Reserve, Myocardial* Humans Image Interpretation, Computer-Assisted / methods* Male Middle Aged Natriuretic Peptide, Brain / blood Peptide Fragments / blood Reproducibility of Results Sensitivity and Specificity Ventricular Dysfunction, Left / blood, etiology, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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