| Incremental prognostic value of myocardial perfusion single photon emission computed tomography for patients with diabetes and chronic kidney disease. | |
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MedLine Citation:
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PMID: 21778926 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: This study estimates whether myocardial perfusion single photon emission computed tomography (SPECT) can predict the prognostic risk of cardiac events among patients with diabetes and relatively mild chronic kidney disease (CKD). METHODS: Data from 2423 patients in the Japanese Assessment of Cardiac Events and Survival Study were examined. Patients were classified into group A (diabetes-, CKD-), B (diabetes-, CKD+), C (diabetes+, CKD-), and D (diabetes+, CKD+). After 3 years of follow-up, the incidence of cardiac events and the ability of myocardial perfusion SPECT to estimate prognosis were evaluated. RESULTS: A total of 119 (4.9%) events (28 cardiac deaths, 25 myocardial infarctions, and 66 severe heart failures) occurred. Each type of event occurred more frequently in CKD compared with non-CKD groups with both diabetic and nondiabetic populations. Risk was higher in patients with high summed stress scores. Risk gradually increased in nondiabetic groups according to the decrease in the estimated glomerular filtration rate and roughly consisted of two diabetic groups with a cutoff of eGFR equal to 50 ml/min. CONCLUSION: A high incidence of cardiac events is associated with CKD in both nondiabetic and diabetic patients. Summed stress scores obtained by myocardial perfusion SPECT have a highly incremental value for predicting the cardiac prognosis of patients with diabetes and CKD. These scores are useful for the risk stratification of asymptomatic patients with relatively mild renal dysfunction requiring neither dialysis nor renal transplantation. |
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Authors:
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Chio Okuyama; Kenichi Nakajima; Tsuguru Hatta; Shigeyuki Nishimura; Hideo Kusuoka; Akira Yamashina; Tsunehiko Nishimura |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-20 |
Journal Detail:
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Title: Nuclear medicine communications Volume: - ISSN: 1473-5628 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto bDepartment of Nuclear Medicine, Kanazawa University Hospital, Kanazawa cDivision of Nephrology, Department of Medicine, Ohmihachiman Community Medical Center, Shiga dDivision of Cardiology, Saitama Medial School Hospital, Saitama eOsaka National Hospital, Osaka fSecond Department of Internal Medicine, Tokyo Medical University Hospital, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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