| Incremental value of PET/CT Over CT for mediastinal nodal staging of non-small cell lung cancer: Comparison between patients with and without idiopathic pulmonary fibrosis. | |
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MedLine Citation:
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PMID: 20651192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We aimed to compare the incremental value of FDG PET/CT over CT for the assessment of mediastinal nodal status between patients with non-small cell lung cancer (NSCLC) and idiopathic pulmonary fibrosis (IPF) and those with NSCLC but without IPF. MATERIALS AND METHODS: Forty-two patients with NSCLC and IPF (mean age, 66 years) were matched to 168 patients with NSCLC but without IPF (mean age, 65 years). Patients underwent surgical mediastinal nodal staging after both integrated PET/CT and contrast-enhanced CT scans had been obtained. Histopathologic nodal assessment served as the reference standard. RESULTS: PET/CT had better specificity (91% [29/32 patients] vs 47% [15/32]; p = 0.0002) and accuracy (83% [35/42] vs 50% [21/42]; p = 0.001) than CT did in patients with IPF. In patients without IPF, PET/CT was better than CT alone with regard to sensitivity (62% [26/42] vs 40% [17/42]; p = 0.0067), specificity (96% [121/126] vs 84% [106/126]; p = 0.0002), and accuracy (88% [147/168] vs 73% [123/168]; p < 0.0001). Thus, the incremental accuracy of PET/CT, which was 33% (14/42) for patients with IPF and 14% (24/168) for patients without IPF (p = 0.0041), was mainly the result of improved specificity. CONCLUSION: PET/CT offers significantly increased accuracy versus CT in mediastinal nodal staging in patients with NSCLC and IPF compared with patients with NSCLC but without IPF, mainly because of improved specificity. |
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Authors:
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Tae Yeon Jeon; Kyung Soo Lee; Chin A Yi; Man Pyo Chung; O Jung Kwon; Byung-Tae Kim; Young Mog Shim |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 195 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 370-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Non-Small-Cell Lung / complications, diagnosis* Female Humans Lung Neoplasms / complications, diagnosis* Male Mediastinal Neoplasms / complications, diagnosis* Neoplasm Staging Positron-Emission Tomography / methods* Pulmonary Fibrosis / complications, diagnosis* Reproducibility of Results Sensitivity and Specificity Subtraction Technique* Tomography, X-Ray Computed / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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