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Incremental Diagnostic Value of Regional Myocardial Blood Flow Quantification Over Relative Perfusion Imaging With Generator-Produced Rubidium-82 PET.
MedLine Citation:
PMID:  21873801     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Myocardial blood flow (MBF) can be measured with positron emission tomography (PET) and its quantification should provide diagnostic information beyond that obtained through standard visual analysis. However, this possibility has not been fully studied with PET and generator-produced rubidium-82 ((82)Rb). We evaluated regional MBF in segments with and without ischemia using (82)Rb PET in patients with coronary artery disease (CAD). Methods and Results: Rest and stress (82)Rb PET and coronary angiography were performed for 12 patients with CAD. Based on angiography and relative (82)Rb perfusion images, segments were classified into 4 groups (Group A: myocardial ischemia with >70% diameter stenosis; Group B: no ischemia with stenosis; Group C: no ischemia without stenosis; Group D: ischemia without stenosis). Rest MBF was similar among the 4 groups. Groups A and B showed reduced hyperemic MBF compared with Group C (P<0.05 vs. Group C) [Group A (n=16) 1.28±0.58ml·min(-1)·g(-1); Group B (n=11) 1.72±0.64ml·min(-1)·g(-1); Group C (n=9) 2.60±1.09ml·min(-1)·g(-1); Group D (n=2) 2.33ml·min(-1)·g(-1)]. Coronary flow reserves were inversely correlated with percent diameter stenosis (r=0.76, P<0.0001). Conclusions: Segments with ischemia and coronary stenosis had reduced hyperemic MBF. Segments with coronary stenosis without ischemia also had reduced hyperemic MBF compared with non-stenotic segments. MBF quantification using (82)Rb PET may provide additional diagnostic information.
Authors:
Keiichiro Yoshinaga; Chietsugu Katoh; Osamu Manabe; Ran Klein; Masanao Naya; Mamoru Sakakibara; Shiro Yamada; Robert A Dekemp; Hiroyuki Tsutsui; Nagara Tamaki
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-27
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  -     ISSN:  1347-4820     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Photobiology, Hokkaido University Graduate School of Medicine.
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