Document Detail

The Incremental Diagnostic and Prognostic Value of Contemporary Stress Echocardiography in a Chest Pain Unit: Mortality and Morbidity Outcomes from a Real-World Setting.
MedLine Citation:
PMID:  23258477     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Clinical assessment often cannot reliably or rapidly risk-stratify patients hospitalized with suspected acute coronary syndrome (ACS). The "real world" clinical value of stress echocardiography (SE) in these patients is unknown. Thus we undertook this study to assess the feasibility, safety, ability for early triaging and prediction of hard events of SE incorporated into a chest pain unit (CPU) for patients admitted with acute chest pain, non-diagnostic ECG and negative 12 hour troponin. METHODS AND RESULTS: -Accordingly, 839 consecutive patients who underwent clinical, ECG and SE assessments within 24hrs of admission were assessed for feasibility, safety, impact on triaging and discharge, 30-day re-admission rate and were followed-up for hard events (all-cause mortality and acute myocardial infarction [AMI]). Of the 839 patients, 811 (96.7%) had diagnostic SE results. Median time to SE and median length of stay for normal SE patients (77%) were both 1 day. The 30-day re-admission rate was 0.5%. Over long-term follow-up of 27±11 months, 39 hard events (30 deaths & 9 AMI) occurred. Kaplan-Meier estimates of hard events were 0.5% vs. 6.6% in the normal vs. abnormal SE groups respectively in the first year of follow-up (15 events in the first year). Amongst all prognostic variables, only abnormal SE [HR 4.08, 95% CI 2.15-7.72, p <0.001] and advancing age [HR 1.78, 95% CI 1.39-2.37, p< 0.001] predicted hard events in multivariable regression analysis. CONCLUSIONS: -SE incorporated into a CPU has excellent feasibility, provides rapid assessment and discharge with accurate risk stratification of patients with suspected ACS but non-diagnostic ECG and negative 12-hr troponin.
Benoy N Shah; Gothandaraman Balaji; Abdalla Alhajiri; Ihab S Ramzy; Shahram Ahmadvazir; Roxy Senior
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-18
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  -     ISSN:  1942-0080     ISO Abbreviation:  Circ Cardiovasc Imaging     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Northwick Park Hospital, Harrow, and Royal Brompton Hospital and Imperial College, London, United Kingdom;
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