Document Detail

Increasing use of atypical antipsychotics and anticonvulsants during pregnancy.
MedLine Citation:
PMID:  23124892     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To quantify maternal use of atypical antipsychotics, typical antipsychotics, anticonvulsants, and lithium during pregnancy.
METHODS: Tennessee birth and death records were linked to Tennessee Medicaid data to conduct a retrospective cohort study of 296,817 women enrolled in Tennessee Medicaid throughout pregnancy who had a live birth or fetal death from 1985 to 2005.
RESULTS: During the study time period, the adjusted rate of use of any study medication during pregnancy increased from nearly 14 to 31 per 1000 pregnancies (β = 0.08, 95% CI = 0.07, 0.09). Significant increases were reported in use of anticonvulsants alone among mothers with pain and other psychiatric disorders, atypical antipsychotics alone among mothers with bipolar disorders, schizophrenia, unipolar depressive disorders, and other psychiatric disorders, and more than one studied medication for mothers with epilepsy, pain disorders, bipolar disorders, unipolar depressive disorders, and other psychiatric disorders. Significant decreases were reported in use of lithium alone and typical antipsychotics alone for all clinically meaningful diagnosis groups.
CONCLUSIONS: There was a substantial increase in use of atypical antipsychotics alone, anticonvulsants alone, and medications from multiple studied categories among Tennessee Medicaid-insured pregnant women during the study period. Further examination of the maternal and fetal consequences of exposure to these medications during pregnancy is warranted.
Richard A Epstein; William V Bobo; Richard C Shelton; Patrick G Arbogast; James A Morrow; Wei Wang; Rameela Chandrasekhar; William O Cooper
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-05
Journal Detail:
Title:  Pharmacoepidemiology and drug safety     Volume:  22     ISSN:  1099-1557     ISO Abbreviation:  Pharmacoepidemiol Drug Saf     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-03     Completed Date:  2014-02-04     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  9208369     Medline TA:  Pharmacoepidemiol Drug Saf     Country:  England    
Other Details:
Languages:  eng     Pagination:  794-801     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
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MeSH Terms
Anticonvulsants / adverse effects,  therapeutic use*
Antipsychotic Agents / adverse effects,  therapeutic use*
Databases, Factual / statistics & numerical data*
Drug Prescriptions / statistics & numerical data*
Drug Utilization Review / statistics & numerical data*
Guideline Adherence / statistics & numerical data
Linear Models
Medicaid / statistics & numerical data
Mental Disorders / diagnosis,  drug therapy*,  epidemiology
Physician's Practice Patterns / statistics & numerical data
Practice Guidelines as Topic
Pregnancy Complications / diagnosis,  drug therapy*,  epidemiology
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
United States / epidemiology
Grant Support
5 K12 HD 043483-09/HD/NICHD NIH HHS; K12 HD043483/HD/NICHD NIH HHS
Reg. No./Substance:
0/Anticonvulsants; 0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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