| Increasing use of antidepressants in pregnancy. | |
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MedLine Citation:
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PMID: 17547888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to quantify the rate of exposures to antidepressants during pregnancy in a large cohort of women. STUDY DESIGN: This was a retrospective cohort study of 105,335 pregnancies among women enrolled in Tennessee Medicaid from 1999-2003. Pregnancies were classified according to antidepressant exposures during pregnancy using previously validated computerized pharmacy records linked with birth certificates. RESULTS: During the study period, 8.7% of women giving birth had exposure to any antidepressant; 6.2% had exposure to a selective serotonin reuptake inhibitor. Maternal age > 25 years (P < .0001), white race (P < .0001), and education > 12 years (P = .008) were significant predictors of antidepressant exposure. The proportion of pregnancies with antidepressant use increased from 5.7% of pregnancies in 1999 to 13.4% of pregnancies in 2003 (p < .0001). The increase was mostly accounted for by increases in selective serotonin reuptake inhibitor exposures. CONCLUSION: There is an urgent need for further studies that better quantify the fetal consequences of exposure to antidepressants. |
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Authors:
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William O Cooper; Mary E Willy; Stephen J Pont; Wayne A Ray |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 196 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-05 Completed Date: 2007-10-15 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 544.e1-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-2504, USA. william.cooper@vanderbilt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidepressive Agents / therapeutic use* Cohort Studies Depressive Disorder, Major / drug therapy Educational Status European Continental Ancestry Group Female Humans Logistic Models Maternal Age Pregnancy Retrospective Studies Serotonin Uptake Inhibitors / therapeutic use* Tennessee |
| Grant Support | |
ID/Acronym/Agency:
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HHSF223200510010C//PHS HHS; HS-0384/HS/AHRQ HHS |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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