| Increasing prevalence of hypospadias associated with various perinatal risk factors in chinese newborns. | |
| | |
MedLine Citation:
|
PMID: 19371929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To evaluate the increasing trends of hypospadias and identify some of the perinatal risk factors that might be involved in Chinese newborns. METHODS: The records from the neonatal intensive care unit were reviewed during a 10-year period. A case-control study was performed to compare the intrauterine growth status of the infants. Logistic regression analysis was used to assess the independent contribution of maternal factors to the risk of hypospadias. RESULTS: Of 8364 male infants, 75 were diagnosed with hypospadias at birth. The overall incidence trend increased during the 10 years. Hypospadias was present more frequently in infants born small for gestational age (P < .0001), those with a very low birth weight (P < .0001), and preterm infants (P < .0001). An increased risk of hypospadias was found when mothers had had multiple births (odds ratio [OR] 2.58), were living in the countryside (OR 1.60), were engaged in outdoor (OR 1.62) or agricultural (OR 2.41) activities, and when the pregnancy was complicated by hypertension (OR 4.75), pre-eclampsia (OR 7.70), or hepatitis B antigen carrier status (OR 2.68). Maternal age (OR 0.98), parity (OR 0.93), and maternal occupational exposure as a housewife (OR 1.02), businesswoman (OR 1.1), or industrial/production worker (OR 0.84) were not associated with the risk of hypospadias. CONCLUSIONS: We found an increasing trend in the incidence of hypospadias among male infants in Chinese population in the past 10 years. Hypospadias was shown to be associated with poor intrauterine growth, maternal multiple births, living in a rural area, working outdoors and agricultural activities, hepatitis B antigen carrier status, hypertension, and pre-eclampsia of pregnancy. |
| | |
Authors:
|
Ge Sun; Daxing Tang; Jianfeng Liang; Mingyuan Wu |
Related Documents
:
|
15703979 - Risk factors for pulmonary candidiasis in preterm infants with a birth weight of less t... 12855879 - Early coagulopathy predicts mortality in trauma. 1485159 - Fetal growth, preterm birth and infant mortality in relation to work with video display... 10649179 - Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth r... 18762599 - Young maternal age and the risk of neonatal mortality in rural nepal. 17344249 - Pregnancy outcomes in women infected with chlamydia trachomatis: a population-based coh... 23394899 - Promoting safe infant feeding practices - the importance of structural, social and cont... 20046939 - Cortisol reactivity, maternal sensitivity, and infant preference for mother's familiar ... 11015509 - Pilot study of treatment with whole body hypothermia for neonatal encephalopathy. |
Publication Detail:
|
Type: Journal Article Date: 2009-04-15 |
Journal Detail:
|
Title: Urology Volume: 73 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-06-01 Completed Date: 2009-07-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
|
Languages: eng Pagination: 1241-5 Citation Subset: IM |
Affiliation:
|
Neonatal Intensive Care Unit, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China. sunge051266@sina.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Case-Control Studies China / epidemiology Humans Hypospadias / epidemiology* Incidence Infant, Newborn Male Prevalence Retrospective Studies Risk Factors |
| Comments/Corrections | |
Comment In:
|
Urology. 2009 Jun;73(6):1245; author reply 1246
[PMID:
19482144
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanical Function and Gene Expression of alpha(1)-Adrenoceptor Subtypes in Dog Intravesical Ureter...
Next Document: Successful treatment of propofol-induced priapism with distal glans to corporal cavernosal shunt.