Document Detail

Increasing physical education in high school students: effects on concentration of circulating endothelial progenitor cells.
MedLine Citation:
PMID:  18677165     Owner:  NLM     Status:  MEDLINE    
AIMS: Levels of endothelial progenitor cells (EPCs), that can be increased by regular exercise, correlate with vascular function. In the context of primary prevention, the impact of regular physical activity on the amount and function of EPC has not yet been investigated in school children. METHODS: Four sixth grade classes of high school students (n=92) were randomly assigned to either the intervention group (IG) with daily physical exercise (45 min) at school or to the control group (CG) with conventional physical education (PE) (2 h/week). In addition, one sixth grade class at a high school focused on competitive sports (PE) served as a reference group. After 1 school year, exercise capacity and the amount and function of EPCs were evaluated. RESULTS: After 1 year, a significantly higher Vo2max was evident in the intervention group. Nevertheless, exercise capacity did not reach the level of children from PE. In addition, exercise intervention was successful in increasing the amount of EPCs but failed to increase the migratory capacity of the cells. CONCLUSION: The result of this study shows, that intensified, supervised school sports leads to an increase in exercise capacity and EPCs in children. Nevertheless, its effect on primary prevention in cardiovascular disease has to be proven in further longitudinal studies.
Claudia Walther; Volker Adams; Inga Bothur; Kati Drechsler; Sven Fikenzer; Melanie Sonnabend; Beatrice Bublitz; Antje Körner; Sandra Erbs; Martin Busse; Gerhard Schuler
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology     Volume:  15     ISSN:  1741-8267     ISO Abbreviation:  Eur J Cardiovasc Prev Rehabil     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101192000     Medline TA:  Eur J Cardiovasc Prev Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  416-22     Citation Subset:  IM    
Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany.
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MeSH Terms
Antigens, CD34 / analysis
Cardiovascular Diseases / prevention & control
Cell Count
Cell Movement
Endothelial Cells / cytology*,  physiology
Exercise Tolerance
Physical Education and Training*
Primary Prevention
Stem Cells / cytology*,  physiology
Reg. No./Substance:
0/Antigens, CD34

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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