| Increasing the number of 5-HT(1A)-receptors in cortex and hippocampus does not induce mnemonic deficits in mice. | |
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MedLine Citation:
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PMID: 19010345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Even though the role of the serotonin1A (5-HT(1A))-receptor for cognitive processes is undisputed, the exact involvement of pre- and postsynaptic sites remains unexplained. Recently, we introduced a mouse line overexpressing the 5-HT(1A)-receptor in the hippocampus and cortex. In this study we investigated in comparison to wild-type mice their cognitive abilities using the Morris water-maze task and inhibitory avoidance test. Acute effects of pre- and posttraining administered 8-OH-DPAT (0.03-0.3 mg/kg i.p.) were examined in the inhibitory avoidance test. Additionally, habituation learning was studied in the hole-board test. Transgenic mice showed no overall learning deficit. Spatial learning and memory revealed in the Morris water-maze task was comparable to wild-type mice, and both genotypes habituated to the hole-board arena in a similar manner. Comparing the performance of both genotypes in the inhibitory avoidance test, cognitive functions of transgenic mice seemed to be slightly impaired. When 8-OH-DPAT was administered pretraining an amnesic effect was produced only in transgenic mice and only at the highest dose (0.3 mg/kg). Posttraining administered 0.3 mg/kg 8-OH-DPAT did not affect the performance of both genotypes. Overall, the cortical and hippocampal overexpression of the 5-HT(1A)-receptor had no major effect on cognitive functions in mice, suggesting that changes in the 5-HT(1A)-receptor density are not necessarily accompanied with alterations of learning and memory processes. |
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Authors:
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Bettina Bert; Jörg-Peter Voigt; Heike Kusserow; Franz Theuring; André Rex; Heidrun Fink |
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Publication Detail:
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Type: Journal Article Date: 2008-10-31 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 92 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-01-30 Completed Date: 2009-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 76-81 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology and Toxicology, Freie Universität Berlin, Koserstrasse 20, 14195 Berlin, Germany. bert.bettina@vetmed.fu-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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8-Hydroxy-2-(di-n-propylamino)tetralin
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pharmacology Animals Avoidance Learning / drug effects Cerebral Cortex / drug effects*, metabolism* Cues Hippocampus / drug effects*, metabolism* Male Maze Learning / drug effects Memory / drug effects Memory Disorders / chemically induced*, psychology* Mice Mice, Transgenic Receptor, Serotonin, 5-HT1A / agonists* Serotonin Agonists / pharmacology Space Perception / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Agonists; 112692-38-3/Receptor, Serotonin, 5-HT1A; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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