| Increasing lynch syndrome identification through establishment of a hereditary colorectal cancer registry. | |
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MedLine Citation:
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PMID: 23392144 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: : Lynch syndrome contributes to 5% of all colorectal cancers. Patients seen in most surgical clinics have limited or no family histories documented and are rarely assessed for hereditary syndromes. In 2007 a clinic-based hereditary colorectal cancer registry was established to screen for Lynch syndrome and facilitate genetic counseling/testing. OBJECTIVE: : To evaluate the effectiveness of the hereditary colorectal cancer registry to identify high-risk colorectal cancer patients and have them referred for genetic counseling/testing for Lynch syndrome. DESIGN: : A retrospective review and cohort comparison of both prospectively collected and retrospective data. SETTING: : The colorectal surgical clinic at Vanderbilt University Medical Center. PATIENTS: : All newly diagnosed colorectal cancer patients seen between January 2006 and October 2010. MAIN OUTCOME MEASURES: : To assess the identification of colorectal cancer patients at high risk for Lynch syndrome and for the occurrence of genetic counseling/testing before and after the establishment of a hereditary registry by comparing the results from the colorectal cancer patients seen the year prior to the establishment of the registry (January - December 2006, "control period") with those patients seen after initiation of the registry (January 2007 - October 2010, "registry period"). RESULTS: : During the "registry period," 495 colorectal cancer patients were seen in the clinic and 257 (51.9%) were high risk for Lynch syndrome. Forty-nine patients (9.8%) underwent genetic testing, with 27 (5.4%) positive for a gene mutation, of which half were >50 years old. By comparison, in 2006, 115 colorectal cancer patients were seen in the clinic but only 4 patients (3.5%) went on for further assessment, and only 1 had genetic testing. Retrospective assessment showed that at least 22 patients (19.1%) had warranted further investigation in 2006. LIMITATIONS: : This was a single-institution, retrospective review. CONCLUSION: : Establishment of a hereditary colorectal cancer registry with a clinic-based protocol improves identification of Lynch syndrome. |
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Authors:
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Duveen Sturgeon; Tonna McCutcheon; Timothy M Geiger; Roberta L Muldoon; Alan J Herline; Paul E Wise |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 56 ISSN: 1530-0358 ISO Abbreviation: Dis. Colon Rectum Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: United States |
Other Details:
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Languages: eng Pagination: 308-14 Citation Subset: IM |
Affiliation:
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1 Division of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 2 Section of Colon and Rectal Surgery, Washington University in St Louis School of Medicine, St Louis, Missouri. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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