| Increasing the incentive salience of cocaine challenges preference for pup- over cocaine-associated stimuli during early postpartum: place preference and locomotor analyses in the lactating female rat. | |
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MedLine Citation:
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PMID: 17589831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MATERIALS AND METHODS: A three-chambered CPP apparatus was used to compare preferences for chambers associated with IP cocaine vs age-matched pups. Unconditioned stimuli were systematically assigned to the least-preferred chamber of separate groups of dams before conditioning. Control dams verified that unconditioned stimuli were necessary for CPP and stimulus-associated locomotion. RESULTS: Compared with most late postpartum dams (60%), only 31% of early postpartum dams preferred the cocaine-associated chamber (P < 0.05). Substantially more dams preferred the pup-associated chamber during early postpartum (27%) than late postpartum (5%; P < 0.05). Locomotor sensitization emerged across cocaine-conditioning sessions in cocaine-preferring but not pup-preferring dams (P < 0.05). Locomotor rates were consistently lower in preferred vs nonpreferred chambers during test. CONCLUSIONS: After increasing cocaine's incentive salience, more early postpartum dams prefer the cocaine-associated chamber than previously reported (Mattson et al. 2001). However, pup-associated chamber preference was still higher in early vs late postpartum. Pup- and cocaine-preferring dams expressed differences in the induction phase of locomotor sensitization across cocaine conditioning but expressed similar motoric patterns in their preferred chambers at test. |
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Authors:
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Katharine M Seip; Joan I Morrell |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-06-23 |
Journal Detail:
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Title: Psychopharmacology Volume: 194 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-11 Completed Date: 2008-01-03 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 309-19 Citation Subset: IM |
Affiliation:
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Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, USA. kseip@pegasus.rutgers.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Choice Behavior Cocaine / pharmacology* Conditioning, Operant / drug effects* Dopamine Uptake Inhibitors / pharmacology* Female Injections, Intraperitoneal Lactation Maternal Behavior* Motivation Motor Activity / drug effects, physiology Postpartum Period Rats Rats, Sprague-Dawley Reinforcement (Psychology)* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DA014025/DA/NIDA NIH HHS; R01 DA014025-05/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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