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Increasing electrospun scaffold pore size with tailored collectors for improved cell penetration.
MedLine Citation:
PMID:  21371575     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study investigates the use of patterned collectors to increase the pore size of electrospun scaffolds for enhanced cell infiltration. The morphology of the patterned scaffolds was investigated by SEM and showed that the collector pattern was accurately mimicked by the electrospun fibres. We observed an enlargement in the pore size and in the pore size distribution compared to conventional electrospinning. Mechanical testing revealed that the mechanical properties could be tailored, to some extent, according to the patterning and that the patterned scaffolds were softer than the standard electrospun scaffolds. When 3T3 fibroblasts were seeded onto patterned collectors, improved cell infiltration was observed. Cells were able to penetrate up to 250 μm compared to 30 μm in the standard scaffolds. This increase in the depth of infiltration occurred as early as 24 hours post seeding and remained constant over 7 days.
Authors:
Cédryck Vaquette; Justin Cooper-White
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-28
Journal Detail:
Title:  Acta biomaterialia     Volume:  -     ISSN:  1878-7568     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Affiliation:
Tissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Old Cooper Road, St. Lucia, 4072, Queensland, Australia.
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