Document Detail

Increasing detection rates of birth defects by prenatal ultrasound leading to apparent increasing prevalence. Lessons learned from the population-based registry of birth defects of Barcelona.
MedLine Citation:
PMID:  16231328     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the evolving trends in prenatal ultrasound detection of birth defects and to suggest a method to avoid the bias generated by an increasing detection rate, when comparing different time periods. METHODS: In the population-based registry of birth defects of Barcelona (REDCB), 1976 cases with birth defects (1462 newborns and 514 terminations of pregnancy) were observed among 99 753 pregnancies, from 1992 to 1999. Detection rates for isolated birth defects by anatomical systems were evaluated. Since an increasing prevalence was observed in some birth defects systems, adjustment for detection rates was suggested. RESULTS: A rise in prevalence was observed in isolated birth defects involving internal organs (central nervous, respiratory, digestive, and urinary systems). Ultrasound detection rates increased in all system groups of isolated birth defects during the study period, except for cardiovascular defects. Early detection rates (before 23 weeks of pregnancy) increased in all but three systems (cardiovascular, genital and tegument). CONCLUSIONS: The apparent rise in the observed prevalence of certain birth defects may be largely due to improvements in prenatal detection methods. Population-based registries are able to measure the impact of evolving prenatal diagnosis in order to avoid biases and establish the prevalence of birth defects more accurately.
Joaquín Salvador; Antoni Borrell; Anna Lladonosa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  25     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-28     Completed Date:  2006-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  991-6     Citation Subset:  IM    
Copyright Information:
Copyright 2005 John Wiley & Sons, Ltd.
Servei d'Informació Sanitària, Institut de Medicina i Salut, Agència de Salut Pública, Barcelona, Spain.
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MeSH Terms
Congenital Abnormalities / epidemiology*,  ultrasonography
Fetal Diseases / epidemiology*,  ultrasonography
Infant, Newborn
Mass Screening
Population Surveillance
Pregnancy Outcome
Retrospective Studies
Spain / epidemiology
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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