Document Detail

Increasing acclimation period improves the reproducibility of short-heating local thermal hyperemia.
MedLine Citation:
PMID:  23154278     Owner:  NLM     Status:  Publisher    
OBJECTIVES: The axon reflex (AR) can be induced by the activation of afferent C-fibers during local skin heating. The previously used long-heating local thermal hyperemia (LTH) protocols tested AR flare by normalizing to endothelial-mediated maximal vasodilatation to adjust capillary heterogeneity when the recording sites were randomly selected. The AR flare induced by short local heating can be reproducible without using the data from subsequent longer heating for normalization when the recording sites were fixed with holders in the same session. The aim of this study was to investigate the effect of acclimation period on the intersession reproducibility of short-heating LTH when the recording sites were relocated after a longer interval of 1-3days. METHODS: After 30 or 60min acclimation, LTH with 5min heating was assessed on bilateral human forearms using single-point laser Doppler flowmetry. The test was repeated at the same recording sites again at the same time 1-3days later. Baseline and heating blood flux were analyzed and the data were expressed as different forms. Reproducibility of two tests was assessed using coefficient of variation (CV) and intra-class correlation coefficient (ICC) statistics. RESULTS: The intersession reproducibility of peak cutaneous vascular conductance (CVC) (CV=18.38%, ICC=0.82), peak CVC change (CV=20.38%, ICC=0.83 and 4min area-under-the-curve (AUC) (CV=18.66%, ICC=0.75) of the right forearm and time to peak (CV=16.84%, ICC=0.52) of the left forearm were acceptable after 30min acclimation. When the acclimation period was increased to 60min, all of these data except 4min AUC of both sides reached an acceptable level. CONCLUSIONS: The AR flare induced by short local heating is reproducible when the recording sites are relocated by a predefined rule. The reproducibility of LTH on right forearm is different from that on left forearm, and increasing acclimation period improves the reproducibility.
Chung-Shin Huang; Shwu-Fen Wang; Yuan-Feen Tsai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Microvascular research     Volume:  -     ISSN:  1095-9319     ISO Abbreviation:  Microvasc. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Department of Physiology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Section 1, Taipei 100, Taiwan (ROC). Electronic address:
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