| Increasing severity of pectus excavatum is associated with reduced pulmonary function. | |
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MedLine Citation:
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PMID: 21429515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether pulmonary function decreases as a function of severity of pectus excavatum, and whether reduced function is restrictive or obstructive in nature in a large multicenter study. STUDY DESIGN: We evaluated preoperative spirometry data in 310 patients and lung volumes in 218 patients aged 6 to 21 years at 11 North American centers. We modeled the impact of the severity of deformity (based on the Haller index) on pulmonary function. RESULTS: The percentages of patients with abnormal forced vital capacity (FVC), forced expiratory volume in 1 second (FEV(1)), forced expiratory flow from 25% exhalation to 75% exhalation, and total lung capacity findings increased with increasing Haller index score. Less than 2% of patients demonstrated an obstructive pattern (FEV(1)/FVC <67%), and 14.5% demonstrated a restrictive pattern (FVC and FEV(1) <80% predicted; FEV(1)/FVC >80%). Patients with a Haller index of 7 are >4 times more likely to have an FVC of ≤80% than those with a Haller index of 4, and are also 4 times more likely to exhibit a restrictive pulmonary pattern. CONCLUSIONS: Among patients presenting for surgical repair of pectus excavatum, those with more severe deformities have a much higher likelihood of decreased pulmonary function with a restrictive pulmonary pattern. |
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Authors:
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M Louise Lawson; Robert B Mellins; James F Paulson; Robert C Shamberger; Keith Oldham; Richard G Azizkhan; Andre V Hebra; Donald Nuss; Michael J Goretsky; Ronald J Sharp; George W Holcomb; Walton K T Shim; Stephen M Megison; R Lawrence Moss; Annie H Fecteau; Paul M Colombani; Alan B Moskowitz; Joshua Hill; Robert E Kelly |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2011-03-22 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 159 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-18 Completed Date: 2011-10-19 Revised Date: 2012-01-30 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 256-61.e2 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Mathematics and Statistics, Kennesaw State University, Kennesaw, GA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Disease Progression Female Follow-Up Studies Forced Expiratory Flow Rates / physiology* Funnel Chest / complications, diagnosis*, physiopathology Humans Male Prognosis Prospective Studies Radiography, Thoracic Respiratory Insufficiency / diagnosis, etiology*, physiopathology Severity of Illness Index Spirometry Tomography, X-Ray Computed Vital Capacity / physiology* Young Adult |
| Comments/Corrections | |
Erratum In:
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J Pediatr. 2012 Jan;160(1):181 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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