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Increasing Prevalence of Peripheral Artery Occlusive Disease in Hemodialysis Patients: A 2-Year Follow-Up.
MedLine Citation:
PMID:  22008782     Owner:  NLM     Status:  Publisher    
INTRODUCTION:: Peripheral artery occlusive disease (PAOD) has been reported to be prevalent in hemodialysis patients and influence their mortality. Ankle-brachial index (ABI) <0.9 is a reliable marker for PAOD. The aims of the 2-year longitudinal study were to assess whether there was a progression in PAOD and to find out the determinants of ABI progression in hemodialysis patients. METHODS:: This study enrolled 237 routine hemodialysis patients and 154 patients completed the 2-year follow-up. The ABI was measured by an ABI-form device at baseline and at the first and second year follow-up. The change in ABI (ΔABI) was defined as ABI measured at the second year follow-up minus ABI measured at baseline. RESULTS:: The prevalence of ABI <0.9 increased yearly (10.4%, 22.7% and 27.9%, respectively; P < 0.001) and the values of ABI decreased yearly (1.11 ± 0.16, 0.97 ± 0.17 and 0.96 ± 0.19, respectively; P < 0.001) in the 154 follow-up patients. Multiple stepwise analysis identified fasting glucose level, calcium-phosphorous product, high-sensitivity C-reactive protein and homocysteine level as independent determinants of ΔABI. CONCLUSIONS:: Our results demonstrated the prevalence of PAOD increased and the values of ABI decreased yearly in hemodialysis patients. The ABI progression was associated with high fasting glucose level, high calcium-phosphorous product, high-sensitivity C-reactive protein and low homocysteine levels.
Szu-Chia Chen; Ho-Ming Su; Jer-Ming Chang; Wan-Chun Liu; Jer-Chia Tsai; Yi-Chun Tsai; Ming-Yen Lin; Shang-Jyh Hwang; Hung-Chun Chen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-17
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  -     ISSN:  1538-2990     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Division of Nephrology (scc, jmc, wcl, jct, yct, myl, sjh, hcc), Division of Cardiology (hms), Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine (scc, hms, jmc, wcl), Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University; and Faculty of Medicine (hms), Faculty of Renal Care (jmc, jct, sjh, hcc), College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
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