Document Detail


The increasing prevalence of atrial fibrillation among hemodialysis patients.
MedLine Citation:
PMID:  21233416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A half million Americans have ESRD, which puts them at high risk for cardiovascular disease and poor outcomes. Little is known about the epidemiology of atrial fibrillation among patients with ESRD. We analyzed data from annual cohorts (1992 to 2006) of prevalent hemodialysis patients from the United States Renal Data System. In each cohort, we searched 1 year of medical claims for relevant diagnosis codes to determine the prevalence of atrial fibrillation. Among 2.5 million patient observations, 7.7% had atrial fibrillation, with the prevalence increasing 3-fold from 3.5% (1992) to 10.7% (2006). The number of affected patients increased from 3620 to 23,893 (6.6-fold) during this period. Older age, male gender, and several comorbid conditions were associated with increased risk for atrial fibrillation. Compared with otherwise similar Caucasians, the prevalence of atrial fibrillation rates was substantially lower for blacks, Asians, and Native Americans. One-year mortality was twice as high among hemodialysis patients with atrial fibrillation compared with those without (39% versus 19%), and this increased risk was constant during the 15 years of the study. In conclusion, the prevalence of diagnosed atrial fibrillation among patients receiving hemodialysis in the United States is increasing, varies by race, and remains associated with substantially increased mortality. Identifying potentially modifiable risk factors for incident atrial fibrillation requires further investigation.
Authors:
Wolfgang C Winkelmayer; Amanda R Patrick; Jun Liu; M Alan Brookhart; Soko Setoguchi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-01-13
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  22     ISSN:  1533-3450     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-03     Completed Date:  2011-03-17     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-57     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Stanford University School of Medicine, 780 Welch Road, Suite 106, Palo Alto, CA 94304, USA. wcw1@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans
Aged
Atrial Fibrillation / epidemiology*,  ethnology,  etiology
European Continental Ancestry Group
Female
Humans
Male
Middle Aged
Prevalence
Renal Dialysis / adverse effects*,  mortality
Grant Support
ID/Acronym/Agency:
1R21DK077336/DK/NIDDK NIH HHS; R21 DK077336/DK/NIDDK NIH HHS; R21 DK077336-01A1/DK/NIDDK NIH HHS; R21 DK077336-02/DK/NIDDK NIH HHS
Comments/Corrections
Comment In:
J Am Soc Nephrol. 2011 Feb;22(2):203-5   [PMID:  21289210 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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