Document Detail

Increasing incidence of Ehrlichia chaffeensis and Anaplasma phagocytophilum in the United States, 2000-2007.
MedLine Citation:
PMID:  21734137     Owner:  NLM     Status:  MEDLINE    
Ehrlichia chaffeensis causes human monocytic ehrlichiosis, and Anaplasma phagocytophilum causes human granulocytic anaplasmosis. These related tick-borne rickettsial organisms can cause severe and fatal illness. During 2000-2007, the reported incidence rate of E. chaffeensis increased from 0.80 to 3.0 cases/million persons/year. The case-fatality rate was 1.9%, and the hospitalization rate was 49%. During 2000-2007, the reported incidence of A. phagocytophilum increased from 1.4 to 3.0 cases/million persons/year. The case-fatality rate was 0.6%, and the hospitalization rate was 36%. Rates among female patients were lower than among male patients for ehrlichiosis (rate ratio = 0.68) and anaplasmosis (rate ratio = 0.70). Most (80%) ehrlichiosis and anaplasmosis cases met only a probable case definition, although, use of a polymerase chain reaction to confirm infections increased during 2000-2007. Heightened reporting of these diseases will likely continue with improving recognition, changing surveillance practices, and appropriate application of diagnostic assays.
F Scott Dahlgren; Eric J Mandel; John W Krebs; Robert F Massung; Jennifer H McQuiston
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  85     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-07     Completed Date:  2011-09-15     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  124-31     Citation Subset:  AIM; IM    
Division of Vectorborne Infectious Diseases, National Center for Enteric, Zoonotic, and Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
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MeSH Terms
Anaplasma phagocytophilum / isolation & purification*
Anaplasmosis / epidemiology*,  microbiology
Centers for Disease Control and Prevention (U.S.)
Child, Preschool
Ehrlichia chaffeensis / isolation & purification*
Ehrlichiosis / epidemiology*,  microbiology
Infant, Newborn
Middle Aged
Population Surveillance
Tick-Borne Diseases / epidemiology*,  microbiology
United States / epidemiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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