Document Detail

Increasing dwell time of mitomycin C in the upper tract with a reverse thermosensitive polymer.
MedLine Citation:
PMID:  22998421     Owner:  NLM     Status:  MEDLINE    
MATERIALS AND METHODS: Using a porcine model, four animals were treated ureteroscopically with both upper urinary tracts receiving MMC mixed with iodinated contrast. One additional animal received MMC percutaneously. The treatment side had ureteral outflow blocked with a reverse thermosensitive polymer plug. MMC dwell time was monitored fluoroscopically and intrarenal pressures measured. Two animals were euthanized immediately, and three animals were euthanized 5 days afterward.
RESULTS: In control kidneys, drainage occurred at a mean of 5.3±0.58 minutes. Intrarenal pressures stayed fairly stable: 9.7±14.0 cm H20. In treatment kidneys, dwell time was extended to 60 minutes, when the polymer was washed out. Intrarenal pressures in the treatment kidneys peaked at 75.0±14.7 cm H20 and reached steady state at 60 cm H20. Pressures normalized after washout of the polymer with cool saline. Average washout time was 11.8±9.6 minutes. No histopathologic differences were seen between the control and treatment kidneys, or with immediate compared with delayed euthanasia.
CONCLUSIONS: A reverse thermosensitive polymer can retain MMC in the upper urinary tract and appears to be safe from our examination of intrarenal pressures and histopathology. This technique may improve the efficacy of topical chemotherapy in the management of upper tract urothelial carcinoma.
Agnes J Wang; Zachariah G Goldsmith; Andreas Neisius; Gaston M Astroza; Olugbemisola Oredein-McCoy; Muhammad W Iqbal; W Neal Simmons; John F Madden; Glenn M Preminger; Brant A Inman; Michael E Lipkin; Michael N Ferrandino
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-06
Journal Detail:
Title:  Journal of endourology / Endourological Society     Volume:  27     ISSN:  1557-900X     ISO Abbreviation:  J. Endourol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-08     Completed Date:  2013-09-12     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8807503     Medline TA:  J Endourol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  288-93     Citation Subset:  IM    
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MeSH Terms
Contrast Media / diagnostic use
Kidney / drug effects,  radiography
Mitomycin / pharmacology*
Polymers / pharmacology*
Sus scrofa
Time Factors
Ureter / drug effects*,  pathology,  radiography
Reg. No./Substance:
0/Contrast Media; 0/Polymers; 50SG953SK6/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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