Document Detail


Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters.
MedLine Citation:
PMID:  20714137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: We tested whether feeding hamsters diets varying in alpha-linolenic acid (ALA) content and low in linoleic acid (LA) could increase the tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) to the same extent as a fish oil-supplemented diet.
METHODS: For 5 weeks, 60 hamsters were fed 1 of the following 5 diets containing 2% of total dietary energy (TE) as LA and either 0.5% (diet A), 1% (diets B and E), 2% (diet C), or 4% (diet D) ALA of TE, so that the ratio of LA/ALA was 4:1, 2:1, 1:1, or 1:2. Diet E was supplemented with fish oil at the level of 0.2% of total energy intake. At the end of the study, overnight-fasted hamsters were sacrificed, and blood and tissues were collected.
RESULTS: Tissue levels of ALA, EPA, DPA, and DHA rose in proportion to the increase in the dietary ALA level (p < 0.01); however, the levels of DHA reached a plateau at ALA intakes above 1% (p < 0.01). These changes were accompanied by decreases in arachidonic acid with or without increases in LA levels (p < 0.01). Hamsters fed diet D had similar or higher EPA, DPA, and DHA tissue levels to those fed diet E (p < 0.01).
CONCLUSIONS: In hamsters, diets containing 4% energy as ALA and 2% energy as LA can increase the tissue levels of EPA, DPA, and DHA to the same extent as feeding 0.2% energy as fish oil.
Authors:
Alfred A Aziz; Cristina Cruz-Hernandez; Louise J Plouffe; Valerie Casey; Chaowu Xiao; W M Nimal Ratnayake
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Publication Detail:
Type:  Journal Article     Date:  2010-08-12
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  57     ISSN:  1421-9697     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  50-8     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
Affiliation:
Nutrition Research Division, Health Products and Food Branch, Health Canada, Ottawa, Ont., Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cricetinae
Diet*
Docosahexaenoic Acids / analysis
Eicosapentaenoic Acid / analysis
Energy Intake*
Fatty Acids, Unsaturated / analysis
Fish Oils / administration & dosage
Food, Fortified*
Linoleic Acid / administration & dosage
Male
alpha-Linolenic Acid / administration & dosage*
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Fish Oils; 1553-41-9/Eicosapentaenoic Acid; 2197-37-7/Linoleic Acid; 25167-62-8/Docosahexaenoic Acids; 25448-00-4/docosapentaenoic acid; 463-40-1/alpha-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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