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Increases of stromelysin messenger-RNA expression in ras-transformed ref cells in-vivo.
MedLine Citation:
PMID:  21566998     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Interstitial collagenase and stromelysin mRNA expression was examined in six rat cell lines isolated after transfection of embryo fibroblasts with polyomavirus large-T and T24-ras oncogenes. Increased levels of stromelysin mRNA were observed in tumors formed by cells with low levels of stromelysin expression before injection, whereas interstitial collagenase mRNA levels were not elevated in tumors. The lung colonizing - but not the chemoinvasive capacity - of two of these cell lines increased following growth in vivo. The increase in stromelysin expression in tumors was not necessarily paralleled by an increase in ras expression. These findings may be relevant to the phenomenon of clonal dominance of metastatic cells in primary tumors.
Authors:
G Engel; P Popowicz; S Linder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of oncology     Volume:  4     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  2011-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  891-6     Citation Subset:  -    
Affiliation:
KAROLINSKA INST,RADIUMHEMMET,DEPT GEN ONCOL,DIV EXPTL,S-17176 STOCKHOLM,SWEDEN. KAROLINSKA HOSP,S-17176 STOCKHOLM,SWEDEN.
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