Document Detail


Increases of plasma eosinophil major basic protein levels late in pregnancy predict onset of labor.
MedLine Citation:
PMID:  3472249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Major basic protein (MBP), the core of the eosinophil granule, is a potent toxin for parasites and mammalian cells; it also causes histamine release from mast cells and basophils. Plasma levels of MBP are increased in all pregnant women, and MBP has been localized by immunofluorescence to placental X cells and placental-site giant cells. Analyses of plasma MBP levels during pregnancy showed a striking correlation between increases late in the third trimester and spontaneous onset of labor. In one case with premature labor, the plasma MBP level also was increased coincidentally with labor. In contrast, in cases of prolonged gestation in which labor was induced, there were no late increases in MBP levels. Also, uterine contraction during spontaneous labor or oxytocin-induced labor did not cause elevations of plasma MBP. Measurement of plasma MBP levels in pregnancy may be useful for the prediction of labor and for the development of new means of intervention for premature labor and prolonged gestation.
Authors:
T L Wasmoen; C B Coulam; K M Leiferman; G J Gleich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  84     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-09     Completed Date:  1987-06-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3029-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Proteins / analysis*
Eosinophil Granule Proteins
Female
Humans
Labor, Obstetric / blood*
Laboratory Techniques and Procedures
Placental Lactogen / blood
Pregnancy / blood*
Pregnancy Trimester, Third
Radioimmunoassay
Ribonucleases*
Grant Support
ID/Acronym/Agency:
AI09728/AI/NIAID NIH HHS; AI15231/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Eosinophil Granule Proteins; 9035-54-5/Placental Lactogen; EC 3.1.-/Ribonucleases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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