| Increases of plasma eosinophil major basic protein levels late in pregnancy predict onset of labor. | |
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MedLine Citation:
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PMID: 3472249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Major basic protein (MBP), the core of the eosinophil granule, is a potent toxin for parasites and mammalian cells; it also causes histamine release from mast cells and basophils. Plasma levels of MBP are increased in all pregnant women, and MBP has been localized by immunofluorescence to placental X cells and placental-site giant cells. Analyses of plasma MBP levels during pregnancy showed a striking correlation between increases late in the third trimester and spontaneous onset of labor. In one case with premature labor, the plasma MBP level also was increased coincidentally with labor. In contrast, in cases of prolonged gestation in which labor was induced, there were no late increases in MBP levels. Also, uterine contraction during spontaneous labor or oxytocin-induced labor did not cause elevations of plasma MBP. Measurement of plasma MBP levels in pregnancy may be useful for the prediction of labor and for the development of new means of intervention for premature labor and prolonged gestation. |
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Authors:
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T L Wasmoen; C B Coulam; K M Leiferman; G J Gleich |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 84 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-06-09 Completed Date: 1987-06-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3029-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Proteins
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analysis* Eosinophil Granule Proteins Female Humans Labor, Obstetric / blood* Laboratory Techniques and Procedures Placental Lactogen / blood Pregnancy / blood* Pregnancy Trimester, Third Radioimmunoassay Ribonucleases* |
| Grant Support | |
ID/Acronym/Agency:
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AI09728/AI/NIAID NIH HHS; AI15231/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Eosinophil Granule Proteins; 9035-54-5/Placental Lactogen; EC 3.1.-/Ribonucleases |
| Comments/Corrections | |
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