| Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia. | |
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MedLine Citation:
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PMID: 18601914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Increased systemic levels of myeloperoxidase (MPO) have been reported in patients with acute myocardial ischemia. We studied the association between exercise-induced myocardial ischemia measured by myocardial perfusion scintigraphy (MPS) and the magnitude and time course of changes in MPO levels in humans. METHODS: One hundred and twenty six patients underwent symptom limited exercise MPS. Myocardial ischemia was assessed semi-quantitatively. Plasma samples were taken before the start of exercise (baseline), at maximum exercise and every hour up to 6 h after maximum exercise. RESULTS: Myocardial ischemia was present in 42 (33%) patients. MPO levels rapidly increased during exercise in patients with and without ischemia (to 131% (106-172%) and 145% (121-199%) of baseline, respectively). MPO levels and absolute changes in MPO did not differ between patients with and without ischemia at any time point. None of the patient characteristics, including presence of ischemia, was independently predictive of the absolute increase in MPO levels during exercise. CONCLUSIONS: Exercise related immediate increases in MPO levels do not reflect myocardial ischemia. |
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Authors:
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P M van der Zee; M C Meuwese; H J Verberne; M de Ruijter; J P van Straalen; J C Fischer; A Sturk; B L F van Eck-Smit; E S G Stroes; R J de Winter |
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Publication Detail:
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Type: Journal Article Date: 2008-06-15 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 395 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 146-50 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands. p.m.vanderzee@amc.uva.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Disease / blood, enzymology*, radionuclide imaging* Exercise* Female Humans Male Middle Aged Myocardial Ischemia / enzymology*, physiopathology, radionuclide imaging Peroxidase / blood* Time Factors Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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