Document Detail

Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia.
MedLine Citation:
PMID:  18601914     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increased systemic levels of myeloperoxidase (MPO) have been reported in patients with acute myocardial ischemia. We studied the association between exercise-induced myocardial ischemia measured by myocardial perfusion scintigraphy (MPS) and the magnitude and time course of changes in MPO levels in humans. METHODS: One hundred and twenty six patients underwent symptom limited exercise MPS. Myocardial ischemia was assessed semi-quantitatively. Plasma samples were taken before the start of exercise (baseline), at maximum exercise and every hour up to 6 h after maximum exercise. RESULTS: Myocardial ischemia was present in 42 (33%) patients. MPO levels rapidly increased during exercise in patients with and without ischemia (to 131% (106-172%) and 145% (121-199%) of baseline, respectively). MPO levels and absolute changes in MPO did not differ between patients with and without ischemia at any time point. None of the patient characteristics, including presence of ischemia, was independently predictive of the absolute increase in MPO levels during exercise. CONCLUSIONS: Exercise related immediate increases in MPO levels do not reflect myocardial ischemia.
P M van der Zee; M C Meuwese; H J Verberne; M de Ruijter; J P van Straalen; J C Fischer; A Sturk; B L F van Eck-Smit; E S G Stroes; R J de Winter
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Publication Detail:
Type:  Journal Article     Date:  2008-06-15
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  395     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  146-50     Citation Subset:  IM    
Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Coronary Artery Disease / blood,  enzymology*,  radionuclide imaging*
Middle Aged
Myocardial Ischemia / enzymology*,  physiopathology,  radionuclide imaging
Peroxidase / blood*
Time Factors
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:

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