| Increases in high-density lipoprotein cholesterol with endurance exercise training are blunted in obese compared with lean men. | |
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MedLine Citation:
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PMID: 9160824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effectiveness of endurance exercise training (without concomitant weight loss) for improving lipoprotein lipid levels in obese individuals remains controversial. The purpose of this study was to determine whether lipoprotein lipid responses to endurance exercise training are affected by obesity. Healthy middle-aged and older (57 +/- 2 years) lean (n = 16; body mass index [BMI], 22 to 26 kg/m2), moderately obese (n = 15; BMI, 27 to 30 kg/m2), and obese (n = 15; BMI, 31 to 37 kg/m2) men underwent a 9-month endurance exercise training program. The groups differed in the initial degree of obesity, waist circumference, and waist to hip ratio (WHR), but not in age or maximal aerobic capacity ( VO2max). The obese group had lower baseline levels of high-density lipoprotein cholesterol (HDL-C) and HDL2-C, and higher triglyceride (TG) levels than the lean group. Exercise training increased VO2max to a comparable degree in lean, moderately obese, and obese groups (18%, 24%, and 18%, respectively, P < .01). Exercise training significantly decreased TG levels in all groups, whereas total cholesterol and low-density lipoprotein cholesterol (LDL-C) decreased only in the obese group. Exercise training increased HDL-C and HDL2-C levels in lean (14% and 81%, respectively, P < .05) and moderately obese (7% and 59%, respectively, P < .05) men, whereas neither HDL-C nor HDL2-C changed in obese men. The change in HDL-C correlated negatively with initial BMI (r = -.42, P < .01) and waist circumference (r = -.43, P < .01). These results show that the effects of exercise training on HDL-C are blunted in obese middle-aged and older men, whereas improvements in TG occur independently of the degree of obesity. |
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Authors:
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B J Nicklas; L I Katzel; J Busby-Whitehead; A P Goldberg |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 46 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-06-23 Completed Date: 1997-06-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 556-61 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Maryland, Baltimore, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Composition Humans Lipoproteins / blood Lipoproteins, HDL / blood* Male Middle Aged Obesity / blood*, pathology Physical Education and Training* Physical Endurance* Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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5-K08-AG00497/AG/NIA NIH HHS; K08AG00383/AG/NIA NIH HHS; T32 AG002109/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 0/Lipoproteins, HDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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